| 引用本文: | 严辉,高明亮,查玉玲,陈静梅,濮宗进,郭盛,周桂生,陈佩东,詹志来.香橼化学成分和药理作用研究进展及其质量标志物预测分析[J].中国现代应用药学,2022,39(7):976-988. |
| YAN Hui,GAO Mingliang,ZHA Yuling,CHEN Jingmei,PU Zongjin,GUO Sheng,ZHOU Guisheng,CHEN Peidong,ZHAN Zhilai.Research Progress on Chemical Components and Pharmacological Effects of Citri Fructus and Predictive Analysis on Its Quality Marker[J].Chin J Mod Appl Pharm(中国现代应用药学),2022,39(7):976-988. |
|
| |
|
|
| 本文已被：浏览 1756次 下载 1550次 |
码上扫一扫！ |
|
|
| 香橼化学成分和药理作用研究进展及其质量标志物预测分析 |
|
严辉1, 高明亮1, 查玉玲1, 陈静梅1, 濮宗进1, 郭盛1, 周桂生1, 陈佩东1, 詹志来2
|
|
1.南京中医药大学 中药资源产业化与方剂创新药物国家地方联合工程研究中心/江苏省中药资源产业化过程协同创新中心, 南京 210023;2.中国中医科学院中药资源中心/道地药材国家重点实验室培育基地, 北京 100700
|
|
| 摘要: |
| 香橼为中国传统的理气中药，其应用广泛、疗效确切。本文对香橼化学成分和药理作用的研究现状进行综述，其成分主要包括挥发油类、黄酮类、香豆素类、生物碱类和萜类，共计167种化合物被报道。香橼在抗氧化、抗炎、抗过敏、抗菌、抗肿瘤等方面具有良好的药理活性。基于质量标志物的基本概念，从成分特有性、成分有效性、成分可测性3个方面对香橼的质量标志物进行预测分析，建议考虑将柠檬烯、柠檬醛、柚皮苷、橙皮苷、柠檬苦素和香橼中具有的芳樟醇、α-蒎烯、β-蒎烯、丙酸松油酯、蛇床子素及枸橼中的川陈皮素、辛弗林作为香橼药材的质量标志物。质量标志物的确定可为建立科学合理的质量评价标准提供理论依据，有助于香橼的深入研究和开发利用。 |
| 关键词: 香橼 化学成分 药理作用 质量标志物 预测分析 |
| DOI：10.13748/j.cnki.issn1007-7693.2022.07.020 |
| 分类号:R284.1 |
| 基金项目:中央本级重大增减支项目（2060302）；现代农业产业技术体系建设专项（CARS-21）；医疗服务与保障能力提升补助资金“全国中药资源普查”项目（财社〔2019〕39号） |
|
| Research Progress on Chemical Components and Pharmacological Effects of Citri Fructus and Predictive Analysis on Its Quality Marker |
|
YAN Hui1, GAO Mingliang1, ZHA Yuling1, CHEN Jingmei1, PU Zongjin1, GUO Sheng1, ZHOU Guisheng1, CHEN Peidong1, ZHAN Zhilai2
|
|
1.National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine/Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China;2.State Key Laboratory of Dao-di Herbs Breeding Base/National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
|
| Abstract: |
| Citri Fructus is a well-known traditional Chinese medicine with surely curative efficacy on regulating the Qi, which has been widely applied in clinical treatments. In this paper, the research advances of Citri Fructus on chemical constituents and pharmacological effects were comprehensively summarized. There were 167 kinds of compounds which have been reported, including volatile oils, flavonoids, coumarins, alkaloids and terpenes. Citri Fructus has good pharmacological activity in anti-oxidation, anti-inflammatory, anti-allergic, anti-bacterial, anti-tumor. The concept of quality marker was introduced and a predictive analysis of Citri Fructus about quality marker was performed in terms of component specificity, constituent validity and component measurability. It is suggested that dipentene, citral, naringin, hesperidin and limonin and compounds in Citrus wilsonii Tanaka(linalool, α-pinene, β-pinene, terpinyl propionate and osthole), as well as two compounds isolated from Citrus medica L. (nobiletin, synephrine) were considered as quality markers. This paper not only provided a theoretical basis for the establishment of quality control standard, but promoted in-depth research and utilization of Citri Fructus. |
| Key words: Citri Fructus chemical constituent pharmacological effect quality marker predictive analysis |
|
|
|
|
