| 引用本文: | 杜伟,陈慧,黄思行,黄崇刚,张莉.常见药物毒性相关的肠道菌群研究进展[J].中国现代应用药学,2022,39(24):3322-3325. |
| DU Wei,CHEN Hui,HUANG Sixing,HUANG Chonggang,ZHANG Li.Research Progress of Gut Microflora Related to Common Drug Toxicity[J].Chin J Mod Appl Pharm(中国现代应用药学),2022,39(24):3322-3325. |
|
| 摘要: |
| 肠道菌群在物质信息传递、代谢等方面发挥重要作用,随着生物技术的进步,人们对肠道菌群与宿主健康的关系有了进一步的认识。近年来的研究发现,肠道菌群与某些药物毒性存在相关性。本文总结了药物肝毒性、肾毒性、神经毒性和生殖及幼龄毒性相关的肠道菌群研究成果,以期为药物毒理研究提供参考。 |
| 关键词: 肠道菌群 药物 毒性 |
| DOI：10.13748/j.cnki.issn1007-7693.2022.24.022 |
| 分类号:R969 |
| 基金项目:重庆市科技局技术创新与应用发展项目(cstc2020jscx-lyggX0004)；重庆市中药研究院基本科研项目(jbky20200014) |
|
| Research Progress of Gut Microflora Related to Common Drug Toxicity |
|
DU Wei, CHEN Hui, HUANG Sixing, HUANG Chonggang, ZHANG Li
|
|
Chongqing Academy of Chinese Materia Medica/Chongqing Drug Safety Evaluation Center, Chongqing 400065, China
|
| Abstract: |
| Gut microflora plays an important role in material information transmission and metabolism. With the progress of biotechnology, researchers have a further understanding of the relationship between gut microflora and host health. Recent studies have found that there is a correlation between gut microflora and the toxicity of some drug. This paper reviews the research on gut microflora related to drug hepatotoxicity, nephrotoxicity, neurotoxicity, reproductive and juvenile toxicity, in order to provide reference for drug toxicology research. |
| Key words: gut microflora drug toxicity |
