儿童药物制剂存在的问题及其创新开发策略

李永圆; 陈晨; 王海霞<sup>*</sup>; 李正; 朱贝贝

引用本文:	李永圆,陈晨,王海霞,李正,朱贝贝.儿童药物制剂存在的问题及其创新开发策略[J].中国现代应用药学,2022,39(12):1597-1603.
	LI Yongyuan,CHEN Chen,WANG Haixia,LI Zheng,ZHU Beibei.Problems and Innovative Development Strategies of Children's Pharmaceutical Preparations[J].Chin J Mod Appl Pharm(中国现代应用药学),2022,39(12):1597-1603.

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儿童药物制剂存在的问题及其创新开发策略
李永圆¹, 陈晨¹, 王海霞^1,2, 李正^1,2, 朱贝贝¹
1.天津中医药大学, 中药制药工程学院, 天津 301617;2.天津中医药大学, 组分中药国家重点实验室, 天津 301617

摘要:

儿童药物制剂广受关注，但目前儿童药物制剂还存在制剂种类少、辅料安全性低、规格不适宜、服药依从性差等问题。本研究针对儿童药物制剂存在的问题，概述了一些儿童药物制剂的创新开发策略，尤其分析指出3D打印技术在创新儿童药物制剂开发中的优势及应用前景，以期为新型儿童药物制剂开发提供思路。

关键词: 儿童药物制剂服药依从性 3D打印个性化灵活性

DOI：10.13748/j.cnki.issn1007-7693.2022.12.014

分类号:R94

基金项目:重大新药创制"国家科技重大专项(2018ZX09201-011);国家自然科学基金项目(82003944)

Problems and Innovative Development Strategies of Children's Pharmaceutical Preparations

LI Yongyuan¹, CHEN Chen¹, WANG Haixia^1,2, LI Zheng^1,2, ZHU Beibei¹

1.Tianjin University of Traditional Chinese Medicine, College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin 301617, China;2.Tianjin University of Traditional Chinese Medicine,State Key Laboratory of Component- based Chinese Medicine, Tianjin 301617, China

Abstract:

Children's pharmaceutical preparations have received a lot of attention. However, current children's pharmaceutical preparations still have group problems such as fewer types of preparations, low excipient safety, inappropriate specifications and poor compliance with medication. In view of the problems of children's pharmaceutical preparations, this review summarized some innovative development strategies for children's pharmaceutical preparations, especially analyzing and pointing out the advantages and application prospects of 3D printing technology in the development of innovative children's pharmaceutical preparations. This review can provide ideas for the development of new pharmaceutical preparations for children.

Key words: children's pharmaceutical preparations medication compliance 3D printing personalization flexibility