基于钙离子驱动的药物负载构建光响应性介孔硅纳米粒的研究

张睿; 刘栗杉; 邓益斌; 陶婧<sup>*</sup>

引用本文:	张睿,刘栗杉,邓益斌,陶婧.基于钙离子驱动的药物负载构建光响应性介孔硅纳米粒的研究[J].中国现代应用药学,2022,39(7):861-867.
	ZHANG Rui,LIU Lishan,DENG Yibin,TAO Jing.Study of Calcium Ion-driven Drug Loading for Light-responsive Mesoporous Silica Nanoparticles[J].Chin J Mod Appl Pharm(中国现代应用药学),2022,39(7):861-867.

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基于钙离子驱动的药物负载构建光响应性介孔硅纳米粒的研究
张睿¹, 刘栗杉¹, 邓益斌¹, 陶婧²
1.苏州大学药学院, 江苏苏州 215123;2.苏州大学附属第一医院药学部, 江苏苏州 215006

摘要:

目的提高介孔硅纳米粒(mesoporous silicon nanoparticles，MSNs)中药物负载量，并使其具备光响应性等功能。方法本研究采用模板法制备氨基化的介孔硅纳米粒(MSN-NH₂)，并通过钙离子负载的MSNs(MSN-Ca)诱导化疗药物阿霉素(Doxorubicin，Dox)及光热治疗药物Cypate、二氢卟吩e6(Ce6)的高效负载，制得光响应性载单药或多药的MSNs，并对其理化性质及释药特性进行研究。结果钙离子可有效负载于MSNs内，并可以诱导Dox、Cypate、Ce6在MSNs孔道内的高效负载，其载药量可分别达到(28.5±1.4)%，(36.8±1.5)%，(36.6±1.7)%；MSN-Ca还可以实现Dox、Cypate、Ce6中的2种或3种药物共同负载。负载Cypate的MSNs具有良好的光热升温效果。载Dox的MSNs具有酸性pH响应性释放Dox的特点。785 nm激光照射可明显增强MSN-Ca-Dox/Cypate的Dox释放，具有光响应性释药的特点。结论钙离子驱动的药物负载策略在多功能MSNs的构建及其抗肿瘤协同治疗研究中具有重要作用。

关键词: 介孔硅纳米粒药物递送系统化学治疗光热治疗

DOI：10.13748/j.cnki.issn1007-7693.2022.07.001

分类号:R944

基金项目:国家自然科学基金青年项目（81703512，31500811）

Study of Calcium Ion-driven Drug Loading for Light-responsive Mesoporous Silica Nanoparticles

ZHANG Rui¹, LIU Lishan¹, DENG Yibin¹, TAO Jing²

1.College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China;2.Department of Pharmacy, The First Affiliated Hospital of Soochow University, Suzhou 215006, China

Abstract:

OBJECTIVE To improve the drug loading capacity of mesoporous silicon nanoparticles(MSNs) and make it photoresponsive. METHODS This study used the template method to prepare aminated mesoporous silica nanoparticles (MSN-NH₂), and induced the efficient loading of chemotherapeutic agent Doxorubicin(Dox) and the photothermal therapeutic agents(Cypate) and Ce6 within MSNs through the calcium ion-driven drug loading strategy(MSN-Ca), resulting in light-responsive MSNs with single or multiple drugs, and their physical and chemical properties and drug release characteristics had been studied. RESULTS Calcium ions could be effectively loaded into MSNs, and they induced the efficient loading of Dox, Cypate and Ce6 in the pores of the MSNs. The drug loading capacities were (28.5±1.4)%, (36.8±1.5)% and (36.6±1.7)%, respectively. MSN-Ca was capable of co-loading two or three drugs among Dox, Cypate and Ce6. The MSNs loaded with Cypate exhibit a photothermal effect. Dox-loaded MSNs had the characteristic of releasing Dox in response to acidic pH. The Doxorubicin release of light-responsive MSN-Ca-Dox/Cypate was enhanced significantly upon laser irradiation at 785 nm. CONCLUSION This calcium ion-driven drug loading strategy plays an important role in the construction of multifunctional MSNs and expedites the development of anti-tumor synergistic therapy.

Key words: mesoporous silica nanoparticles drug delivery system chemotherapy photothermal therapy