| 引用本文: | 谌洪媛,刘大权,陈思维,王肖,潘薇,李棋,谢伟全,贺冬秀.顺铂联合用药治疗乳腺癌的研究进展[J].中国现代应用药学,2022,39(13):1775-1782. |
| CHEN Hongyuan,LIU Daquan,CHEN Siwei,WANG Xiao,PAN Wei,LI Qi,XIE Weiquan,HE Dongxiu.Research Progress of Cisplatin-based Combined Therapy in the Treatment of Breast Cancer[J].Chin J Mod Appl Pharm(中国现代应用药学),2022,39(13):1775-1782. |
|
| 摘要: |
| 乳腺癌发病率持续上升，严重影响女性健康。其治疗手段从手术治疗到化、放疗，再到内分泌治疗与免疫治疗，不断更新，但化疗仍是晚期乳腺癌或发生乳腺外转移的主要临床治疗手段。顺铂是治疗乳腺癌的一线化疗药物，但其不良反应和耐药性限制了其临床应用。目前众多研究报道顺铂联合其他药物可减轻顺铂不良反应、克服其耐药性，从而提高抗乳腺癌效果。本文拟对顺铂与天然活性成分、化疗药、抗体以及核酸类药联合治疗乳腺癌的最新研究进展进行综述，以期为乳腺癌联合治疗方案的选择提供参考。 |
| 关键词: 顺铂 乳腺癌 联合用药 作用机制 |
| DOI：10.13748/j.cnki.issn1007-7693.2022.13.018 |
| 分类号:R285.5 |
| 基金项目:湖南省教育厅重点科研基金项目（20A442）；湖南省自然科学基金项目（2019JJ40256） |
|
| Research Progress of Cisplatin-based Combined Therapy in the Treatment of Breast Cancer |
|
CHEN Hongyuan, LIU Daquan, CHEN Siwei, WANG Xiao, PAN Wei, LI Qi, XIE Weiquan, HE Dongxiu
|
|
Institute of Pharmacology, University of South China, Hengyang 421001, China
|
| Abstract: |
| The incidence of breast cancer continues to rise, which seriously affecting women's health. Its treatment methods including surgical treatment, chemotherapy, radiotherapy, and then endocrine therapy and immunotherapy, which are constantly updating. Chemotherapy is still the main clinical treatment strategy for advanced breast cancer or extramammary metastases. Cisplatin is a first-line chemotherapeutic drug for the treatment of breast cancer, but its adverse reactions and drug resistance limit its clinical application. At present, many studies have reported that cisplatin combined with other drugs can reduce the adverse reactions of cisplatin, overcome its drug resistance, so as to improve the anti-breast cancer effect. This article reviews the latest research progress of cisplatin combined with natural active ingredient, chemotherapeutic drugs, antibody and nucleic acid drugs in the treatment of breast cancer to provide some ideals for the selection of combined treatment for breast cancer. |
| Key words: cisplatin breast cancer combined medication mechanism |
