| 引用本文: | 窦景云,古月瑜,刘旭生.孕烷X受体在肾脏疾病中的研究进展[J].中国现代应用药学,2022,39(11):1503-1508. |
| DOU Jingyun,GU Yueyu,LIU Xusheng.Research Progress of Pregnane X Receptor in Kidney Disease[J].Chin J Mod Appl Pharm(中国现代应用药学),2022,39(11):1503-1508. |
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| 摘要: |
| 核受体是一类在机体内广泛分布的转录因子，在人体生理、病理过程中发挥重要作用。孕烷X受体（pregnane X receptor，PXR）为核受体家族成员之一，参与机体物质代谢，尤其在药物代谢中起关键作用。肾脏是药物代谢的主要器官之一，PXR参与肾脏药物代谢、转运等多种调节并参与多种肾脏疾病的病理生理过程。近年来多项研究关注PXR及其调控作用对肾脏及肾脏疾病的影响。本文将从PXR在肾脏与药物代谢和转运相关酶的相互作用以及PXR在肾脏疾病中的作用等方面进行综述。 |
| 关键词: 孕烷X受体 肾脏疾病 药物代谢 代谢酶 综述 |
| DOI：10.13748/j.cnki.issn1007-7693.2022.11.017 |
| 分类号:R966 |
| 基金项目:国家自然科学基金项目（81903956）；广东省中医药管理局面上项目（20201133）；广州市科技局基础与应用基础研究项目（202102020011） |
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| Research Progress of Pregnane X Receptor in Kidney Disease |
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DOU Jingyun1,2, GU Yueyu2, LIU Xusheng2
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1.The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, China;2.Department of Nephrology, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine(Guangdong Provincial Hospital of Chinese Medicine), Guangzhou 510120, China
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| Abstract: |
| Nuclear receptors are a group of transcription factors that widely distributed in the body and play an important role in both physiological and pathological processes. Pregnane X receptor(PXR) is a member of the nuclear receptor family, which is mainly involved in various biological activities, especially in drug metabolism. Kidney is one of the main organs that take part in the regulation of drug metabolism. PXR is involved in various regulation such as renal drug metabolism and transport, and is involved in the pathophysiological process of various kidney diseases. In recent years, researchers have focused on the effects of PXR and its regulatory functions in kidney and renal diseases. This review mainly discusses the role of PXR on renal physiology, the interaction of PXR and the drug metabolic enzymes and its functions in pathological process in renal diseases. |
| Key words: pregnane X receptor kidney disease drug metabolism metabolic enzymes review |
