蜘蛛毒素及蜘蛛丝的结构与药理作用研究进展

毕建云; 刘尧; 杨文翠; 刘文静

引用本文:	毕建云,刘尧,杨文翠,刘文静.蜘蛛毒素及蜘蛛丝的结构与药理作用研究进展[J].中国现代应用药学,2021,38(19):2475-2480.
	BI Jianyun,LIU Yao,YANG Wencui,LIU Wenjing.Research Progress on Structure and Pharmacology Effect of Spider Toxin and Spider Silk[J].Chin J Mod Appl Pharm(中国现代应用药学),2021,38(19):2475-2480.

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蜘蛛毒素及蜘蛛丝的结构与药理作用研究进展
毕建云¹, 刘尧², 杨文翠², 刘文静²
1.山东中医药大学实验中心, 济南 250355;2.山东中医药大学药学院, 济南 250355

摘要:

蜘蛛来源于野生动物资源，其毒素和蜘蛛丝均具有较强的生物学活性，在生物学领域和材料工程领域应用广阔。本文对国内外蜘蛛毒素及蜘蛛丝的结构及药理作用研究文献进行了总结分析，综述了近年来蜘蛛毒素在对离子通道的作用、神经保护、抗肿瘤、抗菌及对酶活性作用等方面的研究进展，蜘蛛丝在促凝血、神经修复、作为复合载体方面的应用。为今后蜘蛛毒素及蜘蛛丝的进一步研究提供参考，为发展人工养殖及新药研发打下基础。

关键词: 蜘蛛毒素蜘蛛丝结构药理

DOI：10.13748/j.cnki.issn1007-7693.2021.19.024

分类号:R965.1

基金项目:山东省中医药科技发展计划项目（2019-0020）；山东中医药大学科学基金项目（2018zk43）

Research Progress on Structure and Pharmacology Effect of Spider Toxin and Spider Silk

BI Jianyun¹, LIU Yao², YANG Wencui², LIU Wenjing²

1.Shandong University of Traditional Chinese Medicine, Experimental Center, Jinan 250355, China;2.Shandong University of Traditional Chinese Medicine, School of Pharmacy, Jinan 250355, China

Abstract:

Spiders are derived from wild animal resources, and their toxins and spider silk have strong biological activities, which are widely used in the field of biology and material engineering. In this paper, research literature on the structure and pharmacology effect of spider venom and spider silk at home and abroad are summarized and analyzed, focus on the research progress of spider toxin on ion channel, neuroprotection, anti-tumor, antibacterial and enzyme activity in recent years. And the application of spider silk in procoagulant, nerve repair and composite carrier are reviewed as well. It will provide a reference for the further research on spider toxin and spider silk, and lay a foundation for the development of artificial breeding and new drug research.

Key words: spider toxin spider silk structure pharmacology