| 引用本文: | 任锟,邱怡婷,王晓兰,张晗,江燕.基质补偿-电感耦合等离子体质谱法测定脂肪乳注射液中铝元素含量[J].中国现代应用药学,2021,38(20):2572-2574. |
| REN Kun,QIU Yiting,WANG Xiaolan,ZHANG Han,JIANG Yan.Determination of Aluminum in Fat Emulsion Injection by ICP-MS with Matrix Compensation[J].Chin J Mod Appl Pharm(中国现代应用药学),2021,38(20):2572-2574. |
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| 摘要: |
| 目的 建立脂肪乳注射液中铝元素含量的电感耦合等离子体质谱法（ICP-MS）测定方法。方法 采用基质饱和系统，直接稀释制样，在线内标引入方式，以电感耦合等离子体质谱法进行含量分析。结果 铝离子浓度在1~30 ng·mL-1线性关系良好，相关系数（r）为0.999 4，仪器精密度、重复性的RSD均<3%，方法检测限为1.04 μg·L-1，加样回收率为102.0%~113.3%，RSD为3.6%（n=9）。结论 本方法准确、灵敏高、简便可行，可为脂肪乳注射液铝元素含量测定提供有力技术保障。 |
| 关键词: 脂肪乳注射液 基质补偿 电感耦合等离子体质谱 铝元素 |
| DOI：10.13748/j.cnki.issn1007-7693.2021.20.017 |
| 分类号:R917.101 |
| 基金项目: |
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| Determination of Aluminum in Fat Emulsion Injection by ICP-MS with Matrix Compensation |
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REN Kun, QIU Yiting, WANG Xiaolan, ZHANG Han, JIANG Yan
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Sichuan Institute for Drug Control(Sichuan Testing Center for Medical Devices), Chengdu 611731, China
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| Abstract: |
| OBJECTIVE To establish an inductively coupled plasma mass spectrometry(ICP-MS) method for the determination of aluminum in Fat Emulsion injection. METHODS Using matrix saturation system, direct dilution preparation and online internal standard introduction, the content was analyzed by ICP-MS. RESULTS The linear range of aluminum was 1-30 ng·mL-1, and the correlation coefficient(r) was 0.999 4, the RSDs of instrument precision and reproducibility were all <3%, the detection limit of the method was 1.04 μg·L-1, and the recoveries were 102.0%-113.3% with RSD of 3.6%(n=9). CONCLUSION The method is accurate, sensitive, simple and feasible, and can provide strong technical support for the determination of aluminum in Fat Emulsion injection. |
| Key words: Fat Emulsion injection matrix compensation ICP-MS aluminum |
