| 引用本文: | 王帅,杨欣欣,李天娇,包永睿,孟宪生.基于相关性分析的气滞胃痛颗粒挥发油促肠动力谱效关系研究[J].中国现代应用药学,2022,39(14):1835-1840. |
| WANG Shuai,YANG Xinxin,LI Tianjiao,BAO Yongrui,MENG Xiansheng.Study on the Spectrum Effect Relationship of Volatile Oil of Qizhi Weitong Granules in Promoting Intestinal Motility Based on Correlation Analysis[J].Chin J Mod Appl Pharm(中国现代应用药学),2022,39(14):1835-1840. |
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| 基于相关性分析的气滞胃痛颗粒挥发油促肠动力谱效关系研究 |
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王帅1,2,3,4, 杨欣欣1,2,3, 李天娇1,2,3,4, 包永睿1,2,3, 孟宪生1,2,3
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1.辽宁中医药大学药学院, 辽宁 大连 116600;2.辽宁省中药多维分析专业技术创新中心, 辽宁 大连 116600;3.辽宁省现代中药研究工程实验室, 辽宁 大连 116600;4.大连市民族药天然活性成分研究与开发重点实验室, 辽宁 大连 116600
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| 摘要: |
| 目的 探讨气滞胃痛颗粒挥发油促肠动力的谱效关系，为气滞胃痛颗粒的质量控制提供实验基础。方法 建立气滞胃痛颗粒挥发油GC-MS指纹图谱；采用半固体糊炭末推进法，以小肠推进率为指标测定挥发油促肠动力的药理药效，灰色关联度分析结合偏最小二乘回归法建立特征指纹峰与促肠动力药效的谱效模型。结果 8个不同配伍组指纹图谱中有44个共有峰，其中辛醛、D-柠檬烯、顺-葛缕醇、香芹酮、cypera-2,4-diene、β-朱栾、香附烯、β-古巴烯、桉油烯醇、6-isopropenyl-4,8a-dimethyl-1,2,3,5,6,7,8,8a-octahydro-naphthalen-2-ol为潜在药效物质。结论 本研究为确定气滞胃痛颗粒复方促肠动力药效质控指标成分提供实验依据。 |
| 关键词: 气滞胃痛颗粒 挥发油 半固体糊炭末推进法 GC-MS指纹图谱 谱效关系 |
| DOI：10.13748/j.cnki.issn1007-7693.2022.14.007 |
| 分类号:R284.1 |
| 基金项目:辽宁省重点研发计划项目(2020JH2/10300088)；辽宁省自然科学基金项目(2019-ZD-0946，2020-MZLH-35) |
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| Study on the Spectrum Effect Relationship of Volatile Oil of Qizhi Weitong Granules in Promoting Intestinal Motility Based on Correlation Analysis |
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WANG Shuai1,2,3,4, YANG Xinxin1,2,3, LI Tianjiao1,2,3,4, BAO Yongrui1,2,3, MENG Xiansheng1,2,3
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1.College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China;2.Liaoning Multi-dimensional Analysis of Traditional Chinese Medicine Technical Innovation Center, Dalian 116600, China;3.Liaoning Province Modern Traditional Chinese Medicine Research and Engineering Laboratory, Dalian 116600, China;4.Dalian Key Laboratory of Research and Development of Natural Active Ingredients for Ethnic Medicine, Dalian 116600, China
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| Abstract: |
| OBJECTIVE To explore the spectrum effect relationship of the volatile oil of Qizhi Weitong granules in promoting intestinal motility, and to provide experimental basis for the quality control of Qizhi Weitong granules. METHODS The GC-MS fingerprint of the volatile oil of Qizhi Weitong granules was established. The pharmacological effect of the volatile oil on promoting intestinal motility was determined by the method of semi-solid paste charcoal powder propulsion, and the spectral effect model of characteristic fingerprint peak and promoting intestinal motility was established by grey correlation analysis combined with partial least square regression. RESULTS There were 44 common peaks in the fingerprints of 8 different compatibility groups, among which octanal, D-limonene, cis-carveol, carvone, Cypera-2,4-diene, β-vatirenene, cyperene, β-copaene, spathulenol, 6-isopropenyl-4,8a-dimethyl-1,2,3,5,6,7,8,8a-octahydro-naphthalen-2-ol were potential pharmacodynamic substances. CONCLUSION This study provides experimental basis for determining the quality control index components of Qizhi Weitong granules in promoting intestinal motility. |
| Key words: Qizhi Weitong granules volatile oil semi-solid paste charcoal powder propulsion method GC-MS fingerprint spectrum effect relationship |
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