| 引用本文: | 惠媛,尹冬,闵冬雨.沙格列汀对2型糖尿病患者平均血糖波动幅度、HOMA表达、β细胞功能的影响[J].中国现代应用药学,2021,38(5):619-623. |
| HUI Yuan,YIN Dong,MIN Dongyu.Effect of Saxagliptin on the Mean Blood Glucose Fluctuation Range, HOMA Expression and β-cell Function in Patients with Type 2 Diabetes Mellitus[J].Chin J Mod Appl Pharm(中国现代应用药学),2021,38(5):619-623. |
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| 摘要: |
| 目的 评价沙格列汀对2型糖尿病患者血糖波动的调节作用。方法 将145例患者随机分为3组，沙格列汀低剂量（SG-L）组、沙格列汀高剂量（SG-H）组、二甲双胍（MG）组，分别给予二甲双胍1 500 mg+沙格列汀2.5 mg、二甲双胍1 500 mg+沙格列汀5 mg、二甲双胍（1 500~2 000 mg）进行治疗。干预后检测其血糖水平、动态血糖及胰岛功能。结果 治疗后，与MG组相比，SG-H组在早餐后2 h、午餐前、午餐后2 h、晚餐前、晚餐后2 h及晚餐后4 h血糖明显降低（P < 0.05）；平均血糖波动幅度、血糖水平标准差、最大血糖波动幅度、平均血糖水平明显降低（P < 0.05）；胰岛素β功能指数明显升高，胰岛素抵抗指数、空腹胰岛素水平均明显降低（P < 0.05）。结论 沙格列汀联合二甲双胍能有效控制不同时间点患者血糖，减少患者血糖波动，同时改善胰岛素β细胞功能，改善2型糖尿病患者的胰岛素抵抗。 |
| 关键词: 二肽基肽酶-4 沙格列汀 二甲双胍 2型糖尿病 血糖波动 |
| DOI：10.13748/j.cnki.issn1007-7693.2021.05.020 |
| 分类号:R969.4 |
| 基金项目:中国博士后科学基金项目（2014M551121）；辽宁中医药大学脏象理论及应用国家教育部重点实验室基础基金项目（LZ2014043）；连云港市卫生科技项目（201510） |
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| Effect of Saxagliptin on the Mean Blood Glucose Fluctuation Range, HOMA Expression and β-cell Function in Patients with Type 2 Diabetes Mellitus |
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HUI Yuan1, YIN Dong1, MIN Dongyu2
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1.Department of Endocrinology Medicine, The First People's Hospital of Lianyungang & Xuzhou Medical University Affiliated Hospital of Lianyungang & The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang 222000, China;2.Experimental Center of Traditional Chinese Medicine, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110032, China
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| Abstract: |
| OBJECTIVE To evaluate the effect of saxagliptin on the regulation of blood glucose fluctuations in patients with type 2 diabetes mellitus. METHODS One hundred forty-five patients were randomly divided into 3 groups, saxagliptin low-dose(SG-L) group, saxagliptin high-dose(SG-H) group, and metformin(MG) group, gave metformin 1 500 mg + saxagliptin 2.5 mg, metformin 1 500 mg + saxagliptin 5 mg, and metformin(1 500-2 000 mg), respectively. The glucose level, dynamic glucose and pancreas islet function were measured. RESULTS After treatment, compared with the MG group, the blood glucose of the SG-H group was significantly reduced 2 h after breakfast, before lunch, 2 h after lunch, and before dinner, 2 h after dinner and 4 h after dinner(P < 0.05); mean blood glucose fluctuation range, standard deviation of blood glucose level, maximum blood glucose fluctuation range, the mean blood glucose level value was significantly reduced(P < 0.05); HOMA-β levels was significantly increased, HOMA-IR and fasting insulin levels were reduced significant(P < 0.05). CONCLUSION Saxagliptin combined with metformin can effectively control glucose in patients at different time points, reduce glucose fluctuation, while improving insulin β-cell function, improving insulin resistance in patients with type 2 diabetes mellitus. |
| Key words: dipeptidyl peptidase-4 saxagliptin metformin type 2 diabetes mellitus glucose fluctuations |
