鬼臼毒素聚合物胶团对人胶质瘤细胞的抑制作用

王耿焕; 沈和平; 金成胜; 黄嬛; 蒋小红; 褚正民<sup>*</sup>; 王翊飞

引用本文:	王耿焕,沈和平,金成胜,黄嬛,蒋小红,褚正民,王翊飞.鬼臼毒素聚合物胶团对人胶质瘤细胞的抑制作用[J].中国现代应用药学,2016,33(10):1248-1251.
	WANG Genghuan,SHEN Heping,JIN Chengsheng,HUANG Xuan,JIANG Xiaohong,CHU Zhengmin,WANG Yifei.Antitumor Activity of Stearic Acid Grafted Chitosan Oligosaccharide Polymeric Micelles Loading Podophyllotoxin Against Human Glioma Cells[J].Chin J Mod Appl Pharm(中国现代应用药学),2016,33(10):1248-1251.

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鬼臼毒素聚合物胶团对人胶质瘤细胞的抑制作用
王耿焕¹, 沈和平¹, 金成胜¹, 黄嬛², 蒋小红², 褚正民¹, 王翊飞¹
1.嘉兴学院附属第二医院, 浙江嘉兴 314000;2.浙江嘉兴学院医学院, 浙江嘉兴 314001

摘要:

目的合成鬼臼毒素聚合物胶团，评价其对人胶质瘤细胞的增殖抑制作用。方法制备鬼臼毒素聚合物胶团，考察其理化性质，通过肿瘤细胞摄取实验，噻唑蓝（MTT）法检测其对U87细胞的增殖抑制作用。结果鬼臼毒素聚合物胶团比游离药物鬼臼毒素对人胶质瘤细胞有更大的增殖抑制作用，显著增加肿瘤细胞内的药物浓度。结论鬼臼毒素聚合物胶团对人脑胶质瘤细胞增殖有明显的抑制作用。

关键词: 鬼臼毒素聚合物胶团抗肿瘤活性人胶质瘤细胞

DOI：10.13748/j.cnki.issn1007-7693.2016.10.006

分类号:

基金项目:浙江省自然科学基金项目（Y2081030）；浙江省医药卫生科技计划（2013KYA199）

Antitumor Activity of Stearic Acid Grafted Chitosan Oligosaccharide Polymeric Micelles Loading Podophyllotoxin Against Human Glioma Cells

WANG Genghuan¹, SHEN Heping¹, JIN Chengsheng¹, HUANG Xuan², JIANG Xiaohong², CHU Zhengmin¹, WANG Yifei¹

1.The Second Affiliated Hospital of Jiaxing University, Jiaxing 314000, China;2.Medical College of Jiaxing University, Jiaxing 314001, China

Abstract:

OBJECTIVE To investigate the effect of stearic acid grafted chitosan oligosaccharide polymeric micelles loading podophyllotoxin(CSO-SA/PPT) on the cell proliferation in human glioma cells. METHODS CSO-SA/PPT were prepared to investigate its physical and chemical properties. U87 cell proliferative activity was measured by tumor cell uptake assay and MTT assay. RESULTS The CSO-SA/PPT had greater inhibition on human glioma cells proliferation compared with free podophyllotoxin formulation. And in vitro drug uptake tests showed that CSO-SA/PPT presented more uptake characteristics than free podophyllotoxin. CONCLUSION CSO-SA/PPT plays an inhibitory role in the cell proliferation in human glioma cells

Key words: podophyllotoxin polymeric micelle antitumour activity human glioma cells