| 引用本文: | 朱思洵,黄子慧,钱佳燕,高璐珏,高敏行.基于数据挖掘探析2004-2019年祛腐生肌法治疗慢性难愈性创面的用药规律[J].中国现代应用药学,2021,38(2):218-224. |
| ZHU Sixun,HUANG Zihui,QIAN Jiayan,GAO Lujue,GAO Minxing.Clinical Medication Regularity in Treatment of Chronic Refractory Wound with Removing Slough and Promoting Growth of Tissue Regeneration 2004-2019: A Data Mining Study[J].Chin J Mod Appl Pharm(中国现代应用药学),2021,38(2):218-224. |
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| 摘要: |
| 目的 基于数据挖掘技术探析现代临床中祛腐生肌法治疗慢性难愈性创面的用药特点及组方规律。方法 检索中国知网、万方、维普数据库中以祛腐生肌法外用治疗慢性难愈性创面的文献，构建方药数据库，通过频次统计、关联规则分析及系统聚类分析进行研究。结果 共纳入117首方药，涉及药物151味，总计频次1 012次，高频药物50味，依次为血竭、冰片、乳香、没药、当归、黄柏等；药物功效分类以拔毒祛腐类、活血化瘀类和清热解毒类为主；在药性方面，四气中寒、温最多，五味中苦、甘、辛最多，归经中归心、肝、肺经为主；剂型上以膏剂为主；关联规则分析得到二项关联29条，三项关联13条；聚类分析得到9个药物组合。结论 现代临床以祛腐生肌法为原则的中医药外用治疗慢性难愈性创面以祛腐为标，以从瘀阻论治和从毒邪论治为本，重视活血化瘀类和清热解毒类药物的配伍使用。 |
| 关键词: 祛腐生肌法 慢性难愈性创面 用药规律 数据挖掘 |
| DOI：10.13748/j.cnki.issn1007-7693.2021.02.016 |
| 分类号:R282.707 |
| 基金项目:2018年南京市卫健委重点项目（ZKX18048）；南京市卫生青年人才项目（QRX17030） |
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| Clinical Medication Regularity in Treatment of Chronic Refractory Wound with Removing Slough and Promoting Growth of Tissue Regeneration 2004-2019: A Data Mining Study |
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ZHU Sixun, HUANG Zihui, QIAN Jiayan, GAO Lujue, GAO Minxing
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Nanjing Intergrated Traditional Chinese and Western Medicine Hospital Affiliated to Nanjing University of Chinese Medicine, Nanjing 210014, China
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| Abstract: |
| OBJECTIVE To discuss the characteristics of clinical medication and regularity of formula construction in treatment of chronic refractory wound with removing slough and promoting growth of tissue regeneration based on data mining. METHODS The databases including CNKI, Wanfang and VIP database were retrieved for searching the documents about treatment of chronic refractory wound with removing slough and promoting growth of tissue regeneration and establishing a database of traditional Chinese medicine formulas and medicinals. The study on the documents was conducted through frequency statistics, association rules analysis and system cluster analysis. RESULTS There were 117 formulas and 1 012 times of the total use frequency included involving 151 medicinals and 50 high-frequent medicinals as followed Draconis Sanguis, Borneolum Syntheticum, Olibanum, Myrrha, Angelicae Sinensis Radix, Phellodendri Chinensis Cortex, etc. The pulling out poison and removing the rotten, promoting blood circulation to remove blood stasis and clear heat and detoxification drugs accounted for the highest percentage. In the study of medicinal properties, Siqi were mainly cold and warm. The five flavors were mainly bitter, sweet, pungent. There were more drugs in the heart meridian, liver and lung meridian. The commonly use dosage forms were paste. There were 29 binomial correlations and 13 trinomial correlations obtained from association rules analysis. There were 9 combinations obtained from clustering analysis. CONCLUSION Modern clinical use of traditional Chinese medicine for the treatment of chronic refractory wounds use the principle of removing saprophylaxis as a symbol, and base on the treatment of stasis and toxic. Its emphasis is placed on the compatible use of the drugs of the sorts of activating blood circulation and removing blood stasis as well as heat-clearing and detoxification drugs. |
| Key words: removing slough and promoting growth of tissue regeneration chronic refractory wound medication regularity data mining |
