| 引用本文: | 王莹,沈泓,高雯雯,郑金琪,武雅文,刘程智,郑成,龚青,陈碧莲,陈欢.新型冠状病毒基因组学研究进展[J].中国现代应用药学,2020,37(5):525-529. |
| WANG Ying,SHEN Hong,GAO Wenwen,ZHENG Jinqi,WU Yawen,LIU Chengzhi,ZHENG Cheng,GONG Qing,CHEN Bilian,CHEN Huan.Advances in Genomics Research of Novel Coronavirus[J].Chin J Mod Appl Pharm(中国现代应用药学),2020,37(5):525-529. |
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| 新型冠状病毒基因组学研究进展 |
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王莹1,2, 沈泓3,4, 高雯雯1,2, 郑金琪3,5, 武雅文1,2, 刘程智1,2, 郑成3, 龚青3, 陈碧莲3,5, 陈欢1,2
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1.浙江省微生物技术与生物信息学研究重点实验室, 杭州 310012;2.浙江天科高新技术发展有限公司, 杭州 310012;3.浙江省食品药品检验研究院, 杭州 310052;4.国家药监局药品微生物检测与预警重点实验室, 杭州 310052;5.浙江省药品接触材料质量控制研究重点实验室, 杭州 310052
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| 摘要: |
| 目的 对新型冠状病毒（SARS-CoV-2）的基因组研究进展进行综述，以期为疫情防控相关研究提供参考。方法 结合国内外最新研究报道，从SARS-CoV-2基因组结构和进化机制等方面，对SARS-CoV-2的研究进展进行归纳与整理。结果与结论 基于基因组序列的遗传进化分析，病毒基因组现阶段没有发生显著的变异和重组，但在人际传播和感染过程中病毒可能发生一定的适应性进化，这对检测和药物研发可能存在影响。未来需要对覆盖全球的患者病毒分离株和野外动物携带病毒株进行基于全基因组测序和进化分析，监控病毒变异和解析适应性进化机制，这有助于疫情防控。 |
| 关键词: 新型冠状病毒 基因组 进化分析 |
| DOI：10.13748/j.cnki.issn1007-7693.2020.05.002 |
| 分类号:R968 |
| 基金项目:浙江省基础公益研究计划项目（LGN20C050001，LGN19C010001） |
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| Advances in Genomics Research of Novel Coronavirus |
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WANG Ying1,2, SHEN Hong3,4, GAO Wenwen1,2, ZHENG Jinqi3,5, WU Yawen1,2, LIU Chengzhi1,2, ZHENG Cheng3, GONG Qing3, CHEN Bilian3,5, CHEN Huan1,2
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1.Key Lab of Zhejiang Provincial Microorganism Information Science Study, Hangzhou 310012, China;2.Zhejiang Tianke High Technology Development Co., Ltd., Hangzhou 310012, China;3.Zhejiang Institute for Food and Drug Control, Hangzhou 310052, China;4.NMPA Key Laboratory for Testing and Risk Warning of Pharmaceutical Microbiology, Hangzhou 310052, China;5.Key Laboratory of Drug Contacting Material Quality Control of Zhejiang Province, Hangzhou 310052, China
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| Abstract: |
| OBJECTIVE To review the advance in the research of the 2019 Novel Coronavirus(SARS-CoV-2), with a view to providing reference for research related to outbreak prevention and control. METHODS On the basis of the latest domestic and foreign articles, the progress of genomics research of SARS-CoV-2 were summed up. RESULTS & CONCLUSION Evolutionary analysis based on genomic sequences suggested that the virus may evolve adaptively during the process of human-to-human transmission and infection, which may affect the effectiveness of current detection and diagnosis. It is suggested that the whole genome-based evolutionary analysis of large-scale virus isolates and wild animals carrying virus strains should be carried, and the adaptive evolution mechanisms of virus variation should be monitored and analyzed, which can provide research basis for epidemic prevention and control. |
| Key words: SARS-CoV-2 genome evolutionary analysis |
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