| 引用本文: | 王维,黄巧玲.柔性脂质体在经皮给药系统中的研究进展[J].中国现代应用药学,2021,38(4):495-502. |
| WANG Wei,HUANG Qiaoling.Research Progress of Flexible Liposome in Transdermal Drug Delivery System[J].Chin J Mod Appl Pharm(中国现代应用药学),2021,38(4):495-502. |
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| 摘要: |
| 柔性脂质体是一种新兴的透皮给药载体，具备高度变形性和优良渗透性，能够用于包载各类功能不同的小分子及大分子药物以增加药物的透皮量和皮肤滞留量，提高药物的局部药效和给药顺应性。本文主要综述柔性脂质体的特点、透皮机制及影响其透皮的因素，并着重介绍近年来柔性脂质体在经皮给药系统中的应用，阐明柔性脂质体广阔的应用前景。 |
| 关键词: 柔性脂质体 经皮给药系统 研究进展 |
| DOI：10.13748/j.cnki.issn1007-7693.2021.04.021 |
| 分类号:R944.9 |
| 基金项目:浙江省医药卫生科技计划项目（2019KY503）；杭州市科技发展计划项目（20191203B114） |
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| Research Progress of Flexible Liposome in Transdermal Drug Delivery System |
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WANG Wei, HUANG Qiaoling
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Department of Pharmacy, Hangzhou Third Hospital, Hangzhou 310009, China
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| Abstract: |
| Flexible liposome is a new type of transdermal drug delivery carrier with high deformability and excellent permeability. It can be used to encapsulate various kinks of small molecules and macromolecular drugs with different functions to increase their transdermal and skin retention, and improve their local efficacy and drug delivery compliance. In this paper, the characteristics and transdermal mechanism of flexible liposome were reviewed. The factors affecting the transdermal transmission of flexible liposomes were also presented. Finally, the application of flexible liposome in transdermal drug delivery system was emphatically introduced to elucidate the broad application prospect of flexible liposomes. |
| Key words: flexible liposome transdermal drug delivery system research progress |
