| 引用本文: | 沈陶冶,郭剑浩,王小娟,姜赛平.急性肺损伤治疗的研究进展[J].中国现代应用药学,2021,38(3):366-370. |
| SHEN Taoye,GUO Jianhao,WANG Xiaojuan,JIANG Saiping.Research Progress in the Treatment of Acute Lung Injury[J].Chin J Mod Appl Pharm(中国现代应用药学),2021,38(3):366-370. |
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| 摘要: |
| 急性肺损伤（acute lung injury，ALI）是临床常见的危重症，其严重阶段即为急性呼吸窘迫综合征（acute respiratory distress syndrome，ARDS），死亡率高达30%~50%，严重威胁人们生命健康。即使患者幸存，肺功能被严重损害，生活质量亦被严重影响，给患者、家庭及社会造成较大的经济负担。ALI的病理机制复杂，其有效治疗是医学界一大难题。目前对ALI的治疗策略主要包括呼吸支持治疗、药物治疗、基因治疗、细胞移植等。本文就ALI的治疗研究进展进行简要综述。 |
| 关键词: 急性肺损伤 药物治疗 基因治疗 细胞移植 |
| DOI：10.13748/j.cnki.issn1007-7693.2021.03.020 |
| 分类号:R969.4 |
| 基金项目:浙江省医药卫生科技计划项目（2017KY345）；浙江省基础公益研究计划项目（LQ20H300003） |
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| Research Progress in the Treatment of Acute Lung Injury |
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SHEN Taoye, GUO Jianhao, WANG Xiaojuan, JIANG Saiping
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Department of Clinical Pharmacy, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
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| Abstract: |
| Acute lung injury(ALI) is a common clinical critical illness. Its exacerbation stage is acute respiratory distress syndrome(ARDS). The mortality rate is as high as 30%-50%, which seriously threatens people's life and health. Even if the patients survive, the function of lung is severely impaired, thus severely affecting the quality of the patients' life and causing a large economic burden on the patient, family and society. The complex pathological mechanisms of ALI make its effective treatment still a tremendous challenge clinically. Presently, the treatment strategies of ALI mainly include respiratory support therapy, drug therapy, gene therapy, cell transplantation and other means. A brief review of the research progress of ALI therapy is presented. |
| Key words: acute lung injury drug therapy gene therapy cell transplantation |
