| 引用本文: | 周逸轩,金银秀,蒋旻昀,杨芳芳,罗俊杰,王玉新,陶雪芬.微针与新型经皮给药载体结合的研究进展[J].中国现代应用药学,2020,37(17):2170-2176. |
| ZHOU Yixuan,JIN Yinxiu,JIANG Minyun,YANG Fangfang,LUO Junjie,WANG Yuxin,TAO Xuefen.Research Progress on Combination of Microneedle and New Transdermal Drug Delivery Carrier[J].Chin J Mod Appl Pharm(中国现代应用药学),2020,37(17):2170-2176. |
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| 摘要: |
| 经皮给药系统具有给药方便、血药浓度稳定、无首过效应等优点，但皮肤的屏障作用使得药物难以透过皮肤。近年来，出现了很多新型经皮给药的药物载体，如脂质体、醇质体、囊泡等，这些能通过化学方法促进药物的经皮渗透。而微针能穿透皮肤角质层形成微孔通道，通过物理方法促进药物的渗透，将微针与新型经皮给药载体结合能显著提高药物的经皮吸收的速率。本研究对微针与新型经皮给药载体结合的最新研究进行了综述，并展望了微针辅助新型药物载体经皮给药的发展前景。 |
| 关键词: 微针 经皮给药 综述 |
| DOI：10.13748/j.cnki.issn1007-7693.2020.17.023 |
| 分类号:R94 |
| 基金项目:浙江省教育厅一般科研项目（Y201738207）；台州市科技计划项目（1802gy10）；2018年浙江省大学生科技创新活动计划暨新苗人才计划（2018R477007） |
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| Research Progress on Combination of Microneedle and New Transdermal Drug Delivery Carrier |
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ZHOU Yixuan, JIN Yinxiu, JIANG Minyun, YANG Fangfang, LUO Junjie, WANG Yuxin, TAO Xuefen
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Chemical Pharmaceutical Research Institute, Taizhou Vocational Technical College, Taizhou 318000, China
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| Abstract: |
| Transdermal drug delivery system has the advantages of convenient administration, stable blood concentration and no first-pass effect, but the barrier effect of skin makes it difficult for drugs to penetrate the skin. In recent years, a lot of new transdermal drug carriers have emerged, such as liposomes, ethosomes, and vesicles, etc., which can promote the transdermal penetration of drugs through chemical methods. Microneedle can penetrate the skin to form microporous channels and promote the penetration of drugs through physical methods. The combination of microneedle and new transdermal drug carriers can significantly improve the efficiency of drug penetration through the skin. The latest research on the combination of microneedle and new transdermal drug delivery vehicles is reviewed, and the development prospect of microneedle assisted new transdermal drug delivery is prospected. |
| Key words: microneedle transdermal administration review |
