|
| 摘要: |
| 目的 综述药动学-药效学(PK-PD)结合模型的研究进展。方法 对近十年来国内外发表的具有代表性的相关文章进行分析、整理和归纳，总结PK-PD结合模型的类型、程序及应用。结果 PK-PD结合模型有4种类型，其在新药研发，个体化给药和临床检测等方面都有广泛的应用，为临床用药提供了有力的指导。结论 PK-PD模型随着研究的深入不断完善，在药物开发和研究中发挥了重要的作用。 |
| 关键词: 药动学 药效学 药动学-药效学结合模型 常用程序 研究进展 |
| DOI： |
| 分类号: |
| 基金项目: |
|
| Recent Advances and Application of Pharmacokinetic-pharmacodynamic (PK-PD) Modeling |
|
SUN Minjie XU Ying
|
| Abstract: |
| OBJECTIVE To review the advances on pharmacokinetic-pharmacodynamic (PK-PD) modeling. METHODS On the basis of analysing and concluding the relevant articles for the last ten years, the types, programs and application of PK-PD modeling were summarized. RESULTS There are four kinds of pharmacokinetic-pharmacodynamic (PK-PD) modeling, which were widely applied on drug development, individual administration and clinical detection, providing useful information to guide clinical medication. CONCLUSION PK-PD modeling has been improved and plays important role in drug development with its deep study. |
| Key words: pharmacokinetic pharmacodynamic pharmacokinetic-pharmacodynamic (PK-PD) modeling common programs rencent advances |
