| 引用本文: | 程光文,曾婧,毛宗福.双黄连注射剂不良反应影响因素的logistic回归分析[J].中国现代应用药学,2010,27(10):948-949. |
| .Logistic Regression Analysis on Influential Factors of ADR Caused by Shuanghuanglian Injection[J].Chin J Mod Appl Pharm(中国现代应用药学),2010,27(10):948-949. |
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| 摘要: |
| 目的 了解双黄连注射剂在临床应用中不良反应的影响因素，为指导临床合理用药提供科学依据。方法 以整群抽样方法，随机抽取静脉滴注双黄连注射剂患者的完整住院病历，采用logistic回归的多因素分析方法，对双黄连注射剂不良反应的影响因素进行了研究。结果 不同性别不良反应有差异，男性高于女性(P<0.05)，用药时间、用药剂量和合并用药均对不良反应发生有影响(P<0.05)。结论 应充分了解双黄连注射剂不良反应的影响因素，注重临床合理用药，减少不良反应发生，保障用药安全。 |
| 关键词: 双黄连注射剂 不良反应 影响因素 logistic回归 |
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| Logistic Regression Analysis on Influential Factors of ADR Caused by Shuanghuanglian Injection |
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CHENG Guangwen1 ZENG Jing1 MAO Zongfu2
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| Abstract: |
| OBJECTIVE To provided the scientific evidence for guiding rational drug use, the influential factors of adverse drug reactions (ADR) of Shuanghuanglian injection were studied. METHODS By cluster sampling, 2 068 integrated medical records used Shuanghuanglian injection were investigated and the influential factors of ADR of Shuanghuanglian injection were analyzed by logistic regression multiplicity. RESULTS The ADR rate in male was significantly higher than that in female (P<0.05). The duration of medication, dose of drug and drug combination had significant influence on the incidence rate of the ADR (P<0.05). CONCLUSION More attention should be paid to rational medication in clinical to decrease the incidence rate of ADR caused by Shuanghuanglian injection and to ensure security of use of drug. |
| Key words: Shuanghuanglian injection ADR influential factors logistic regression |
