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| 摘要: |
| 目的 综述元素硅在先导化合物优化中的应用及其特点，从而为新药设计提供理论依据。方法 对近年来国内外发表的文献进行归纳、总结。 结果与结论 对现有药物或候选药物进行碳/硅交换是一种寻求新化学实体的有效方法。 |
| 关键词: 生物电子等排 有机硅化合物 生物活性 |
| DOI： |
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| Recent Development of Organosilicon Compounds in Drug Discovery |
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LI Hongcai
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| Abstract: |
| OBJECTIVE Review several major features of silicon in optimization of lead compounds, and to provide a theoretical basis for drug design. METHODS Search and summarize the related literatures at home and abroad recently. RESULTS AND CONCLUSION Sila-substitution (C/Si exchange) of existing drugs is an approach to search for new drug-like candidates. |
| Key words: bioisosteres organosilicon compound biological activity |
