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| 摘要: |
| 目的 建立甲磺酸帕珠沙星注射液含量测定的高效液相色谱方法。方法 采用Alltima C18 (250 mm×4.6 mm，5 µm)色谱柱, 以柠檬酸溶液-乙腈-甲醇(84∶16∶2)为流动相，流速1.0 mL·min-1。检测波长243 nm。结果 线性范围为1.423~22.768 μg·mL-1，r=0.999 5，平均回收率(n=9)为99.73%，RSD为0.69%。结论 该法准确、简便，适用于甲磺酸帕珠沙星注射液的含量测定。 |
| 关键词: 甲磺酸帕珠沙星 注射液 含量测定 高效液相色谱法 |
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| Determination of Pazufloxacin Mesilate Infection by HPLC |
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WANG Qiaowen1 SHEN Chunying2 YANG Jingrong3*
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| Abstract: |
| OBJECIVE To establish an HPLC method for assay of pazufloxacin mesilate injection. METHODS The analysis was carried out on Alltima C18 column (250 mm×4.6 mm, 5 µm). The mobile phase was citric acid solution acetonitrile methanol (84∶16∶2), wave length was 243 nm and flow rate 1.0 mL·min-1. RESULTS The liner range of pazufloxacin mesilate was 1.423-22.768 μg·mL-1, r=0.999 5. The average recovery (n=9) was 99.73%, RSD=0.69%. CONCLUSION The method is simple, accurate and can be used for determination of pazufloxacin mesilate infection. |
| Key words: pazufloxacin mesilate infection determination HPLC |
