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| 摘要: |
| 目的 通过正交试验优化五味子滴丸的成型工艺。方法 以滴丸的溶散时限、圆整度及丸重差异等作为综合评定指标，优选出滴丸成型工艺。结果 五味子滴丸制备过程的最佳工艺条件为：以PEG4000-PEG6000(1∶1)为基质，药物-基质1∶4 配比，料温85 ℃，二甲基硅油为冷却剂，冷却液温度10 ℃为最佳条件。结论 该成型工艺成品率高，符合滴丸的质量要求，可用于五味子滴丸制备。 |
| 关键词: 五味子 正交试验 滴丸 制备工艺 |
| DOI： |
| 分类号: |
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| Study on Preparation Process for Wuweizi Dropping Pills |
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YU Jin CUI Baiji ZHANG Xiurong*
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| Abstract: |
| OBJECTIVE To study the preparation technology of Wuwerzi dropping pills by orthogonal design. METHODS Time limit of dissolution, grain roundness and weight variation were used as comprehensive evaluation indexes for selecting good dropping conditions. RESULTS The best pills formatting process were the ratio of PEG 4000 to PEG6000(1∶1), the ratio of Wuwerzi to matrix was 1∶4, the dripping temperature was 85 ℃, methylsiliconoil was used as refrigerant with the temperature of 10 ℃. The moulding probability was highest. CONCLUSION The optimized moulding process results in high finished product rate and good quality which are suitable for the preparation of Wuwerzi dropping pills. |
| Key words: Schisandra chiesis (Turcz.) Baill orthogonal design dropping pills preparation process |
