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| 摘要: |
| 目的 合成尼莫唑。方法 以吗啉与氯乙醇反应，经羟基氯代，再在相转移催化剂存在下与4(5)-硝基咪唑缩合制得目标产物。结果 产物经熔点测定、红外及核磁共振氢谱得到确认。结论 该工艺路线方法简便，原料易得，适合工业化生产。 |
| 关键词: 尼莫唑 合成 相转移催化 |
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| Synthesis of Nimorazole |
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YU Shuhai YANG Jianhui ZHANG Zhiwei
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| Abstract: |
| OBJECTIVE To synthesis nimorazole. METHODS Nimorazole was prepared by reaction of morpholine with 2-chloroethanol, via chlorination, and condensed with 4(5)-nitro-imidazole in the presence of phase-transfer catalyst. RESULTS The structure was identified by mp., IR and 1H-NMR. CONCLUSION The process can be easily controlled and suitable for a scale production. |
| Key words: nimorazole synthesis phase-transfer catalysis |
