| 引用本文: | 康桦,匡荣,姚治,朱社敏,倪维芳.麦芪口服液对D-半乳糖所致衰老模型大鼠的抗氧化作用[J].中国现代应用药学,2010,27(3):190-192. |
| .The Antioxidative Effect of Maiqi Oral Solution on D-Galactose Induced Aging Model Rats[J].Chin J Mod Appl Pharm(中国现代应用药学),2010,27(3):190-192. |
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| 摘要: |
| 目的 研究麦芪口服液对D-半乳糖所致衰老模型大鼠的抗氧化作用。方法 采用腹腔注射D-半乳糖的方法，制作衰老动物模型。60只大鼠随机分成正常对照组、模型组、维生素C阳性对照组和高、中、低3个剂量的麦芪口服液组。测定各组大鼠血清中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活性和丙二醛(MDA)含量。结果 与模型对照组比较，麦芪口服液能明显升高衰老模型大鼠的血清中SOD(P<0.01)和GSH-Px(P<0.05)的活性，减少MDA的含量(P<0.01)。结论 麦芪口服液具有抗氧化作用。 |
| 关键词: 麦芪口服液 抗氧化 衰老模型大鼠 超氧化物歧化酶 谷胱甘肽过氧化物酶 丙二醛 |
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| The Antioxidative Effect of Maiqi Oral Solution on D-Galactose Induced Aging Model Rats |
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KANG Hua KUANG Rong YAO Zhi ZHU Shemin NI Weifang
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| Abstract: |
| OBJECTIVE To investigate the antioxidative effect of Maiqi oral solution (MOS) on aging model rats induced by D-galactose. METHODS Aging rats model was established by administrating D-galactose intraperitoneally. Sixty rats were divided into 6 groups randomly as follows: normal control group, model group, Vit C group, and three different doses of MOS. The activity of SOD, GSH-Px and the level of MDA in blood serum were measured. RESULTS Compared with model group, MOS could significantly improve the activity of SOD and GSH-Px, and markelly decrease the concentration of MDA in blood serum. CONCLUSION MOS has antioxidative effect on aging rats induced by D-galactose. |
| Key words: Maiqi oral solution antioxidation aging model rats SOD GSH-Px MDA |
