| 引用本文: | 马建军,王洁,张小玲,张俭,范宗鹏,黄秀丽.不同剂量阿托伐他汀对高脂血症患者高敏C反应蛋白及颈动脉内膜中层厚度的影响[J].中国现代应用药学,2010,27(1):72-74. |
| .Different Doses of Atorvastatin on Hyperlipidemia in Patients with High-Sensitivity C-Reactive Protein and Carotid Artery Intima-media Thickness[J].Chin J Mod Appl Pharm(中国现代应用药学),2010,27(1):72-74. |
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| 摘要: |
| 目的 观察强化降脂对高脂血症患者高敏C反应蛋白和颈动脉内膜中层厚度(CIMT)的影响。方法 164例高血脂症患者随机分为常规治疗组79例，强化降脂组85例，分别予阿托伐他汀10 mg·d-1或40 mg·d-1。于用药前及用药6个月后测定总胆固醇(TC)，低密度脂蛋白胆固醇(LDL-C)，高密度脂蛋白胆固醇(HDL-C)，甘油三酯(TG)。观察高敏Ｃ反应蛋白(hs-CRP)及CIMT的变化。结果 强化降脂组，hs-CRP由用药前(5.14±0.96)mg·L-1，降至用药6个月时的(1.58±0.25)mg·L-1 (P<0.05)，较常规治疗组(5.16±0.98)mg·L-1降至(2.68±0.5)mg·L-1有更显著的疗效。强化降脂组CIMT由用药前(1.54±0.17)mm，降至用药6个月时的(1.41±0.21)mm (P<0.05)，较常规治疗组(1.54±0.16)mm降至(1.51±0.17)mm有显著的效果。结论 强化降脂治疗能更有效地降低高敏C反应蛋白(hs-CRP)，降低CIMT。 |
| 关键词: 阿托伐他汀 高脂血症 高敏C反应蛋白 血管内皮 |
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| Different Doses of Atorvastatin on Hyperlipidemia in Patients with High-Sensitivity C-Reactive Protein and Carotid Artery Intima-media Thickness |
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MA Jianjun WANG Jie ZHANG Xiaoling ZHANG Jian FAN Zongpeng HUANG Xiuli
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| Abstract: |
| OBJECTIVE To investigate the effect of intensive lipid-lowering hyperlipidemia in patients with high-sensitivity c-reactive protein and carotid artery intima-media thickness (CIMT). METHODS 164 cases of hyperlipidemia were randomly divided into conventional treatment group 79 cases, 85 cases of intensive lipid-lowering group, were to atorvastatin 10 mg·d-1 or 40 mg·d-1. In the former drug use and 6 months after the determination of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglycerides (TG). Observe high sensitive C-reactive protein (hs-CRP) and CIMT. RESULTS The outcome of intensive lipid-lowering group, hs-CRP by the former administration (5.14±0.96)mg·L-1, drug use fell to 6 months at the time of (1.58±0.25)mg·L-1(P<0.05), than conventional treatment group (5.16±0.98)mg·L-1 reduced (2.68±0.5)mg·L-1 have a more significant effect. CIMT group of intensive lipid-lowering drugs by the former (1.54±0.17)mm, drug use fell to 6 months at the time of (1.41±0.21)mm (P<0.05), than the conventional treatment group (1.54±0.16)mm to (1.51±0.17)mm significant results. CONCLUSION Intensive lipid-lowering therapy method is more effective in reducing high-sensitivity C-reactive protein (hs-CRP), reducing CIMT. |
| Key words: atorvastatin hyperlipidemia high-sensitivity C-reactive protein vascular endothelial |
