| 引用本文: | 缪玉山,孙彦甫,陈国明,徐仁南.曲尼司特滴眼液的处方研究[J].中国现代应用药学,2010,27(2):132-134. |
| .Formulation Study of Eye Drops of Tranilast[J].Chin J Mod Appl Pharm(中国现代应用药学),2010,27(2):132-134. |
|
|
| 摘要: |
| 目的 增加曲尼司特的溶解度，筛选出合格的曲尼司特滴眼液处方。方法 以稳定性为指标，拟采用包合、增溶或助溶技术制备曲尼司特滴眼液。结果 以葡甲胺作助溶剂制备的曲尼司特滴眼液在光照(4 000 lx)、低温(4 ℃)、高温(60 ℃)10 d及室温留样考察12个月，物理及化学性质稳定。结论 研制的曲尼司特滴眼液达到设计要求。 |
| 关键词: 曲尼司特 滴眼剂 稳定性 溶解度 处方研究 |
| DOI： |
| 分类号: |
| 基金项目: |
|
| Formulation Study of Eye Drops of Tranilast |
|
MIAO Yushan SUN Yangfu CHEN Guoming XU Rennan
|
| Abstract: |
| OBJECTIVE To screen good formulations of tranilast eye drops by solubilizing. METHODS Tranilast eye drops were prepared by inclusion compound or solubilizers method according to stability. RESULTS The physico-chemical stability was good after storing 10 d under illumination (4 000 lx), 4 ℃, 60 ℃ and 12 months under room temperature. CONCLUSION Tranilast eye drops could be made successfully. |
| Key words: tranilast eye drops stability solubility formulation study |
