| 引用本文: | 张卫国,韩刚,王彬,阎林奇,翟冠钰,范颖.姜黄素固体分散体对2型糖尿病大鼠氧化应激的影响[J].中国现代应用药学,2010,27(1):13-15. |
| .Effect of Curcumin Solid Dispersion on Oxidative Stress in Diabetic Rats[J].Chin J Mod Appl Pharm(中国现代应用药学),2010,27(1):13-15. |
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| 摘要: |
| 目的 研究姜黄素固体分散体对2型糖尿病大鼠氧化应激的影响。方法 以聚乙烯吡咯烷酮(PVP)为载体制备姜黄素固体分散体。大鼠腹腔注射小剂量链脲佐菌素(STZ)建立2型糖尿病模型，随机分成糖尿病模型(MD)组、聚乙烯吡咯烷酮(PVP)组、姜黄素(CU)组、姜黄素固体分散体低剂量(LSD)组、姜黄素固体分散体高剂量(HSD)组。大鼠给药6周后，测定血清及肾脏组织中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)的活力，丙二醛(MDA)的含量。结果 与正常对照组比较，MD组大鼠超氧化物歧化酶、谷胱甘肽过氧化物酶活力显著降低，氧化应激增强；与MD组比较，姜黄素固体分散体组SOD、GSH-Px活力显著提高，MDA含量显著降低。结论 姜黄素固体分散体可显著提高糖尿病大鼠的抗氧化能力，抑制氧化应激。 |
| 关键词: 糖尿病 氧化应激 姜黄素 固体分散体 超氧化物歧化酶 谷胱甘肽过氧化物酶 |
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| Effect of Curcumin Solid Dispersion on Oxidative Stress in Diabetic Rats |
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ZHANG Weiguo1 HAN Gang1* WANG Bin2 YAN Linqi1 ZHAI Guanyu1 FAN Ying1
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| Abstract: |
OBJECTIVE To study the effects of curcumin solid dispersion on the oxidative stress in diabetic rats. METHODS The curcumin solid dispersion was prepared with excipient of polyvinylpyrrolidone. Diabetic rats that were induced by intraperitoneal injection of streptozotacin were randomly divided into five groups: diabetes mellitus (MD) group, polyvinylpyrrolidone (PVP) group, curcumin (CU) group, low dosage of curcumin solid dispersion (LSD) group, high dosage of curcumin solid dispersion (HSD) group. Six weeks after initiating treatment, the superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehtyde (MDA) were examined. RESULTS The diabetic rats compared with control group, the index of kidney increased significantly, the antioxidant capability of kidney decreased significantly; the rats that fed with curcumin solid dispersion compared with diabetic rats, the activity of superoxide dismutase and glutathione peroxidase increased significantly, the content of malondialchehyche decreased significantly. CONCLUSION The curcumin solid dispersion can increase the antioxidant capability of diabetic rats and decrease the oxidantive stress. |
| Key words: diabetes mellitus oxidantive stress curcumin solid dispersion superoxide dismutase glutathione peroxidase |
