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| 摘要: |
| 目的建立气相色谱法测定西地脑中薄荷脑含量的方法。方法在20%PEG-20M色谱柱上，柱温150 ℃, 进样口温度220 ℃，检测器温度230 ℃。结果总薄荷脑平均回收率为99.03%，RSD=0.526%；线性范围0.5～2.5 mg·mL-1。游离薄荷脑平均回收率为98.44%，RSD=1.829%；线性范围0～0.5 mg·mL-1。结论本法简便、快速、准确，可用作西地脑的质量控制。 |
| 关键词: 气相色谱法 薄荷脑 西地脑 西地碘 含量测定 |
| DOI： |
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| Determination of Menthol in Inclusion Complex of Compound Menthol-β-cyclodextrin by GC |
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WANG Honghua，XING Yahong
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| Abstract: |
| OBJECTIVE To establish a GC method for the determination of menthol in inclusion complex of compound menthol-β-cyclodextrin.METHODS A 20%PEG-20M column was used,the temperature of column was 150 ℃,and the sampling and detector was 220 ℃ and 230 ℃,respectively.RESULTS The average recovery of all menthol was 99.03%,RSD=0.523%.The calibration curves of total menthol were linear in the range of 0.5-2.5 mg·mL-1.The average recovery of dissociate menthod was 98.44%,RSD=1.829%.The calibration curves of free menthol were linear in the range of 0-0.5 mg·mL-1.CONCLUSION The method is simple,rapid and accurate,and suitable for the quality control of the inclusion complex of compound menthol-β-cyclodextrin. |
| Key words: GC menthol inclusion complex of compound menthol-β-cyclodextrin cydiodine determination |
