| 引用本文: | 张毅1，李恒华1，江兵1，黄小平1，翁代群1，徐嘉红1，杨大坚1,2*.四乙酰葛根素对离体大鼠胸主动脉环作用初步研究[J].中国现代应用药学,2009,(11):873-875. |
| ZHANG Yi1, LI Henghua1, JIANG Bin1, HUANG Xiaoping1, WENG Daiqun1, XU Jiahong1, YANG Dajian1,2*.Study effects of Tetra-acetylated Puerarin on Isolated Rat Thoracic Aortic Rings[J].Chin J Mod Appl Pharm(中国现代应用药学),2009,(11):873-875. |
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| 摘要: |
| 目的观察四乙酰葛根素(Tp)对离体大鼠胸主动脉环的作用以及作用机制。方法采用大鼠离体胸主动脉环灌流装置，观测四乙酰葛根素对重酒石酸去甲肾上腺素(NA)和氯化钾(KCl)预收缩主动脉环张力的影响。结果四乙酰葛根素对去甲肾上腺素预收缩主动脉环有明显的舒张作用，与空白对照相比，具有显著性差异(P<0.01)；由KCl引起主动脉环预收缩，Tp与空白对照相比，具有统计学差异(P<0.01)，对内皮完整血管环的舒张作用明显强于去内皮血管环(P<0.01)；Tp对NA在无钙液及正常钙液所致离体血管环收缩的舒张作用不明显(P>0.05)。结论四乙酰葛根素的舒血管作用与受体依赖性钙通道和电压依赖性钙通道均有关，并且其舒血管作用可能与内皮有一定关系。 |
| 关键词: 四乙酰葛根素 胸主动脉环 血管舒张 作用机制 |
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| Study effects of Tetra-acetylated Puerarin on Isolated Rat Thoracic Aortic Rings |
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ZHANG Yi1, LI Henghua1, JIANG Bin1, HUANG Xiaoping1, WENG Daiqun1, XU Jiahong1, YANG Dajian1,2*
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| Abstract: |
| OBJECTIVE Study effect of tetra-acetylated puerarin on isolated rats thoracic aortic rings and it's mechanisms. METHODS The thoracic aortic rings of Sprague-Dawley rats were mounted on a perfusion system, and isometric tensions of the aorta rings precontracted with noradrenaline bitartrate (NA) and potassium chloride (KCl) respectively were recorded in vitro. RESULTS Compared with the controls, tetra-acetylated puerarin showed significantly different vasodilation effects on NA-precontracted aortic ring (P<0.01) in normal rats; it showed significantly different vasodilation effects on KCl-precontracted aortic ring (P<0.01), and show significantly different vasodilation effects on aortic ring with or without endothelium (P<0.01) in the same molar concentration; it showed no significantly different vasodilation effects on vascular muscle induced calcium-free solution and normal calcium solution (P>0.05). CONCLUSION Tetra-acetylated puerarin can inhibit the receptor-operated calcium channel and voltage-dependent calcium channel, and it's vasodilator may be related to blood vessel endothelium. |
| Key words: tetra-acetylated puerarin thoracic aortic rings vasodilatation mechanism |
