| 引用本文: | 戚燕，杨庆云，吴松.羟丙基-β-环糊精对匹诺塞林的包合作用研究[J].中国现代应用药学,2009,(10):837-840. |
| QI Yan, YANG Qingyun, WU Song.Study of Pinocembrin-hydroxpropy-β-cyclodextrin Inclusion Compound[J].Chin J Mod Appl Pharm(中国现代应用药学),2009,(10):837-840. |
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| 摘要: |
| 目的测定匹诺塞林在不同浓度羟丙基-β-环糊精溶液中的溶解度曲线，以及包合物的组成量比例和稳定性常数。方法在25 ℃运用相溶解度法进行实验，采用紫外分光光度法测定匹诺塞林在溶液中的浓度。结果随着羟丙基-β-环糊精浓度增加和pH的增大，匹诺塞林的溶解度显著提高。计算了表观稳定常数、确定了不同pH条件下包合物的摩尔比。结论难溶性药物匹诺塞林与羟丙基-β-环糊精可形成1∶1包合物。 |
| 关键词: 羟丙基-β-环糊精 匹诺塞林 溶解度 |
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| Study of Pinocembrin-hydroxpropy-β-cyclodextrin Inclusion Compound |
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QI Yan, YANG Qingyun, WU Song
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| Abstract: |
| OBJECTIVE To investigate the solubilization effects of the inclusion complex of pinocembrin with hydroxypropyl-β-cyclodextrin (HP-β-CD) in aqueous solutions at various pH and to determine the constitutive molar ratio of pinocembrin-hydroxypropyl-β-cyclodextrin inclusion complex and its stability constant．METHODS The solubilization experiment was performed by the phase-solubility method at 25 ℃．The concentration of pinocembrin was determined by the UV spectrophotometric method．RESULTS The apparent solubility of pinocembrin was enhanced noticeably with the increase of HP-β-CD concentration and the increasing pH values．The apparent stability constants were calculated respectively．The molar ratio of the inclusion complex at various pH were studied．The application of HP-β-CD to parenteral formulations of pinocembrin was discussed preliminarily．CONCLUSION An inclusion complex of pinocembrin and HP-β-CD can be formed． |
| Key words: hydroxypropyl-β-cyclodextrin pinocembrin solubility |
