|
| 摘要: |
| 目的评价苦参素联合高效抗逆转录病毒疗法( highly active antiretroviral therapy, HARRT)治疗人免疫缺陷病毒/获得性免疫缺陷综合症(HIV/AIDS)患者的有效性。方法将57例患者随机分为两组，治疗组为36例，接受苦参素联合HARRT治疗，对照组为21例，仅接受HARRT治疗。两组分别在治疗前及治疗2个月，6个月时检测病毒载量，在治疗前及治疗2、4、6个月时检测CD4+T细胞数和血清白介素(IL)-18浓度，组间比较以评价苦参素对HIV/AIDS患者的疗效。结果两组经治疗后均抑制了HIV病毒的复制，在治疗6个月时治疗组抑制效果优于对照组(P＜0.05)，且CD4+T细胞数均有所上升，在治疗2、4、6个月时治疗组更为明显(P＜0.05)，两组治疗后血清IL-18浓度均降低，在治疗6个月时组间比较有统计学意义(P＜0.05)。结论较单纯HARRT治疗而言，苦参素联合HARRT治疗能更有效的抑制病毒复制，改善体内失衡的细胞因子状态，提高机体的免疫力。 |
| 关键词: 苦参素 高效抗逆转录病毒疗法 艾滋病病毒/艾滋病 |
| DOI： |
| 分类号: |
| 基金项目: |
|
| Clinical Study of the Effect of Oxymatrine Combined with Highly Active Antiretroviral Therapy on the Treatment of 36 HIV/AIDS Patients |
|
CAO Huia，WANG Qingbob，ZHAO Weib
|
| Abstract: |
| Objective To evaluate the therapeutic effect of oxymatrine combined with highly active antiretroviral therapy (HAART) on the treatment of HIV/AIDS patients. Methods 57 HIV /AIDS patients were randomized into two groups, control group (n=21) and treatment group (n=36). The control group was treated with HAART, and treatment group was treated with oxymatrine in addition to HAART. The viral loads were determined before treatment and after treatment for 2 months and 6 months. CD4+T lymphocytes and serum IL-18 levels were detected before treatment and after treatment for 2 months, 4 months and 6 months. Results The viral loads were all decreased in two groups after treatment. There was no statistically significant difference between the two groups in 2 months after the treatment, but the significant differences were found 6 months after the treatment(P＜0.05). CD4+T cell counts increased in both groups after the treatment, while in treatment groups CD4+T cell counts were higher than those in control gronps in 2, 4 and 6 months after the treatment (P＜0.05). Serum IL-18 levels were decreased after the treatment in two groups, especially after treatment for 6 months, the significant difference being observed between two groups (P＜0.05). Conclusion Oxymatrine combined with HARRT could more effectively inhibit HIV reproductions, improve body’s immune function and abnormal cytokines levels than the single use of HARRT. |
| Key words: oxymatrine highly active antiretroviral therapy human immunodeficiency virus/acquired immunodeficiency syndrome |
