| 引用本文: | 秦红岩1，段好刚2，魏玉辉1，张冬梅1，李波霞2，武新安1.盐酸二甲双胍在正常大鼠与糖尿病大鼠体内的药动学比较[J].中国现代应用药学,2009,(6):433-436. |
| QIN Hongyan1, DUAN Haogang2, WEI Yuhui1, ZHANG Dongmei1, LI Boxia2, WU Xinan1.Comparison on the Pharmacokinetic of Metformin Hydrochloride between Normal and Diabetic Rats[J].Chin J Mod Appl Pharm(中国现代应用药学),2009,(6):433-436. |
|
|
| 摘要: |
| 目的 比较盐酸二甲双胍在正常大鼠与糖尿病大鼠体内的药动学差异。方法 正常大鼠与糖尿病模型大鼠，分别灌胃给予盐酸二甲双胍后，于不同时间点采集血样，用HPLC测定血药浓度并绘制药-时曲线，用DAS1.0统计软件计算药动学参数。结果 盐酸二甲双胍在正常大鼠与糖尿病大鼠体内的主要药动学参数分别为：Cmax=9.41 μg·mL-1、t1/2=161.8 min、Cl/F=0.079 L·min-1·kg-1；Cmax=20.09 μg·mL-1、t1/2 =1 718.93 min、Cl/F=0.012 L·min-1·kg-1。结论 盐酸二甲双胍在正常大鼠与糖尿病模型大鼠体内的药动学参数有明显差异(P<0.05)。 |
| 关键词: 盐酸二甲双胍 大鼠 糖尿病 药动学 |
| DOI： |
| 分类号: |
| 基金项目: |
|
| Comparison on the Pharmacokinetic of Metformin Hydrochloride between Normal and Diabetic Rats |
|
QIN Hongyan1, DUAN Haogang2, WEI Yuhui1, ZHANG Dongmei1, LI Boxia2, WU Xinan1
|
| Abstract: |
| OBJECTIVE To compare the pharmacokinetic differences of metformin hydrochloride between normal and diabetic rats. METHODS Metformin hydrochloride was orally administrated to the normal and diabetic rats. The blood samples were collected at different time. The concentration of metformin hydrochloride in plasma was determined by HPLC method. The software of DAS1.0 was used to estimate the pharmacokinetic parameters. RESULTS The main pharmacokinetic parameters of metformin hydrochloride in normal and diabetic rats were Cmax=9.41 μg·mL-1, t1/2=161.8 min, Cl/F=0.079 L·min-1·kg-1 and Cmax=20.09 μg·mL-1, t1/2 =1 718.93 min, Cl/F=0.012 L·min-1·kg-1, respectively. CONCLUSION The main pharmacokinetic parameters of metformin hydrochloride in normal and diabetic rats have significant differences (P<0.05) |
| Key words: metformin hydrochloride rats diabetic pharmacokinetics |
