| 引用本文: | 陈梅,黄丽丽.复方孕二烯酮与去氧孕烯炔雌醇治疗围绝经期功能失调性子宫出血的临床疗效比较[J].中国现代应用药学,2009,(5):423-425. |
| CHEN Mei, HUANG Lili.Comparing of Clinical Curative Effect between Gestodene-Compound and Gestodene-Ethinylestradiol Used to Treat Dysfunctional Uterine Bleeding in Peri-menopausal Period[J].Chin J Mod Appl Pharm(中国现代应用药学),2009,(5):423-425. |
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| 摘要: |
| 目的 探讨复方孕二烯酮与去氧孕烯炔雌醇治疗围绝经期功血的临床疗效及安全性。方法 86例围绝经期功血患者随机分为两组。复方孕二烯酮（A组）43例，去氧孕烯炔雌醇（B组）43例，两组患者于流血期分别口服复方孕二烯酮片与去氧孕烯炔雌醇2次·d-1，1片·次-1，待血止后再连续服药20 d，停药。于月经来潮第5天起，再分别口服复方孕二烯酮片与去氧孕烯炔雌醇，1次·d-1，1片·次-1，连服21 d，停药。服药3个周期为1疗程。结果 两组患者均在服药72 h内阴道流血停止，继续服药，无突破性出血。在减量后的周期中，A组突破性出血2例（4.65％），B组突破性出血4例（9.30%），高于A组，但无显著性差异（P>0.05）。其余A组41例（95.35％），B组39例（90.70％）服药期间月经均规律。其它不良反应两者无显著性差异（P >0.05）。无严重不良反应发生。结论 复方孕二烯酮与去氧孕烯炔雌醇适用于各种类型的围绝经期功血治疗，疗效相似，止血效果确切，月经周期控制均良好，简便安全，耐受性好。 |
| 关键词: 复方孕二烯酮 去氧孕烯炔雌醇 围绝经期功血 |
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| Comparing of Clinical Curative Effect between Gestodene-Compound and Gestodene-Ethinylestradiol Used to Treat Dysfunctional Uterine Bleeding in Peri-menopausal Period |
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CHEN Mei, HUANG Lili
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| Abstract: |
| OBJECTIVE To discuss the clinical curative effect and security of gestodene compound and gestodene-ethinylestradiol used to treat dysfunctional uterine bleeding (DUB) in peri-menopausal period. METHODS Eighty-six peri-menopausal DUB patients were randomly devided into two groups. Gestodene-compound(A) group and gestodene- ethinylestradiol(B) group consisted of 43 patients each.Patients in gestodene-compound group were given 1 tablet gestodene- compound per 12 hour in bleeding period,and continued to take in the same dose up to the 20th day after bleeding stopped, then took in 1 tablet of gestodene-compound per day since the fifth day of menstrual period for 21days.And the second group patients were given gestodene-ethinylestradiol in the same way of the gestodene-compound group. RESULTS Both of two groups stopped bleeding within 72 hours after medication.And there was no break-through bleeding again during continuous medication. After the period of decrement A group had 2 patients(4.65%) while B group had 4 patients(9.30%) who had break-through bleeding.There was no significant difference between two groups(P>0.05). Besides these 6 patients, the rest patients were menstruation regular while taking medicine. There was no significant difference between two groups(P >0.05) of the side effect with no severe adverse effect.CONCLUSION Gestodene-compound and gestodene-ethinylestradiol are effective,safe drugs which are applicable for all types of DUB in peri-menopausal period. To keep taking in same dose through the treating period can avoid break-through bleeding with no rise of side effect. |
| Key words: gestodene-compound gestodene-ethinylestradiol dysfunctional uterine bleeding in peri-menopausal period |
