| 引用本文: | 熊建华,孙丽蓉,王淑君,叶晓笑,胡国新.注射用阿洛西林钠在5%木糖醇注射液中的稳定性考察[J].中国现代应用药学,2009,(3):248-251. |
| XIONG Jianhua1,2,SUN Lirong1,WANG Shujun1,YE Xiaoxiao1,HU Guoxin1.Study on Stability of Azlocillin Sodium For Injection in 5% Xylitol Injection[J].Chin J Mod Appl Pharm(中国现代应用药学),2009,(3):248-251. |
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| 摘要: |
| 目的研究注射用阿洛西林钠在5%木糖醇注射液中的稳定性。方法用高效液相色谱法测定阿洛西林钠的含量,用经典恒温加速法和多元线性模型研究温度对阿洛西林钠在5%木糖醇注射液中稳定性的影响。结果各温度下阿洛西林钠百分含量的对数(lgC)与时间(t)具有线性关系,符合一级动力学反应。用经典恒温加速法和多元线性模型预测阿洛西林钠在5%木糖醇注射液的有效期分别为5.09d,5.59d。结论2种方法预测得到的有效期基本一致。在25℃,注射用阿洛西林钠在5%木糖醇注射液应在5d内稳定。 |
| 关键词: 高效液相色谱法 经典恒温加速法 多元线性模型 阿洛西林钠 稳定性 |
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| Study on Stability of Azlocillin Sodium For Injection in 5% Xylitol Injection |
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XIONG Jianhua1,2,SUN Lirong1,WANG Shujun1,YE Xiaoxiao1,HU Guoxin1
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| Abstract: |
| OBJECTIVE To study the stability of azlocillin sodium in 5% xylitol injection.METHODSThe content of azlocillin sodium was determined by HPLC and the effect of temperature on the stability of azlocillin sodium in 5% xylitol injection was detected by classic isothermal accelerated tests and multiple linear model. RESULTSThere was a linearity between the azlocillin contents in the 5% xylitol injection in logarithm (lgC) and time (t) at each temperature.It responded to the first order kinetic reaction. The expiration dates of azlocillin sodium 5% xylitol injection detected by classic isothermal accelerated tests and multiple linear model were 5.09 days and 5.59 days, respectively.CONCLUSIONIts expiration dates are the same calculated by 2 different methods. Azlocillin sodium in 5% xylitol injection was stable within 5d at room temperature (25 ℃). |
| Key words: classical isothermal accelerated tests multiple linear model azlocillin sodium stability |
