| 引用本文: | 曹毅1,张春椿2,熊耀康2.皮炎净颗粒剂中挥发油的提取及包合工艺研究[J].中国现代应用药学,2009,(2):130-133. |
| CAO Yi1, ZHANG Chunchun2, XIONG Yaokang2.Optimization of Volatile Oils Extraction and β-cyclodextrin Inclusion from Piyanjing Granules[J].Chin J Mod Appl Pharm(中国现代应用药学),2009,(2):130-133. |
|
|
| 摘要: |
| 目的探讨皮炎净颗粒剂中挥发油的混合提取及包合最佳工艺路线。方法采用正交设计实验，以挥发油总重量为评价提取工艺指标；以包合物收率、挥发油包合率为评价包合工艺指标。结果挥发油的最佳提取工艺条件是：药材混合加8倍量水、浸泡1 h、加热至沸腾回流8 h；挥发油的最佳包合工艺：挥发油与β-环糊精按1∶6投料、包合温度40 ℃、磁力搅拌3 h。结论按上述工艺条件提取、包合本制剂中的挥发油最为合理。 |
| 关键词: 皮炎净颗粒剂 挥发油 提取 包合 |
| DOI： |
| 分类号: |
| 基金项目: |
|
| Optimization of Volatile Oils Extraction and β-cyclodextrin Inclusion from Piyanjing Granules |
|
CAO Yi1, ZHANG Chunchun2, XIONG Yaokang2
|
| Abstract: |
| OBJECTIVE To specify optimize condition of process for mixture extraction of volatile oils and preparation of β-CD inclusion compound of Piyanjing granules．METHODS Taking weight of volatile oils to evaluate the extraction process and percentage recovery of inclusion compound,transfer rate of oils to evaluate the inclusion process．Orthogonal design was applied．RESULTS The optimum extraction condition was to add eight times amount of water into the mixture of crude drugs，to soak for 1 h，to heat up to boiling and reflux 8 h.The optimum inclusion condition was volatile oils: β-CD in proportion as 1∶6 was mixed, the inclusion temperature was at 40 ℃ and inclusion time was 3 h.CONCLUSION Above condition of process was the most rational in extraction and inclusion of Piyanjing granules. |
| Key words: Piyanjing granules volatile oils extraction inclusion |
