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| 摘要: |
| 目的合成盐酸美利曲辛。方法以邻苯甲酰苯甲酸为起始原料，经还原、酯化、甲基化、环合、氧化、缩合、脱水成盐等7步反应得到盐酸美利曲辛。结果目标化合物经红外光谱、核磁共振氢谱、质谱等确证其化学结构。结论打通了盐酸美利曲辛的合成路线，对工艺进行了优化改进。 |
| 关键词: 盐酸美利曲辛 抗抑郁药 合成 |
| DOI： |
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| Synthesis of Melitracen Hydrochloride |
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CAO Jianjun, LI Qingshan
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| Abstract: |
| OBJECTIVE To synthesize melitracen hydrochloride.METHODS The target compound was prepared from o-benzoylbenzoic acid as a starting material via seven steps including reduction, esterification, methylation, cyclazition, oxidation condensation, anhydration and saltlization.RESULTS The structure of the compounds was confirmed by IR, NMR and MS．CONCLUSION Some improvements for the synthesis of melitracen hydrochloride were made and the synthesis route was feasible. |
| Key words: melitracen hydrochloride antidepressant synthesis |
