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| 摘要: |
| 目的合成阿嗪米特并对其质量进行控制。方法以3,6-二氯哒嗪(2)为起始原料,经巯基取代,酸化,然后与N,N-二乙基氯代乙酰胺缩合得到2-[(6-氯-3-哒嗪基)硫代]-N,N-二乙基乙酰胺。结果反应总收率40.5%,纯度在99.0%以上。结论本法路线简单,适宜放大生产。 |
| 关键词: 阿嗪米特 利胆药 合成 |
| DOI： |
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| Synthesis and Quality Control of Azintamide |
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MEI Zhi-nan,LI Xiao-kuan,LI Yun-fang
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| Abstract: |
| OBJECTIVE To synthesis and control the quality of Azintamide.METHODS Azintamide was synthesized via substitution,acidification and condensation using 3,6-dichloropyridazine as raw material. RESULTS The total yield was 40.5% and purity was above 99.0%.CONC |
| Key words: azintamide choleretic synthesis |
