2型糖尿病大鼠心肌间质胶原代谢的变化及罗格列酮的干预研究

王绵a;张力辉a;赵占胜a;邓永贵a;周红a;郝咏梅a;苏胜偶a;崔炜b

引用本文:	王绵a;张力辉a;赵占胜a;邓永贵a;周红a;郝咏梅a;苏胜偶a;崔炜b.2型糖尿病大鼠心肌间质胶原代谢的变化及罗格列酮的干预研究[J].中国现代应用药学,2007,(2):100-103.
	WANG Miana,ZHANG Li-huia,ZHAO Zhan-shenga,DENG Yong-guia,ZHOU Honga,HAO Yong-meia,SHU Sheng-oua,CUI Weib.The Changes of Collagen Metabolism in Rat Heart with Type 2 Diabetes and Preventive Effect of Rosiglitazone[J].Chin J Mod Appl Pharm(中国现代应用药学),2007,(2):100-103.

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2型糖尿病大鼠心肌间质胶原代谢的变化及罗格列酮的干预研究
王绵a;张力辉a;赵占胜a;邓永贵a;周红a;郝咏梅a;苏胜偶a;崔炜b

作者	单位
王绵a;张力辉a;赵占胜a;邓永贵a;周红a;郝咏梅a;苏胜偶a;崔炜b

摘要:

关键词: 糖尿病心肌间质纤维化基质金属蛋白酶及其组织抑制物噻唑烷二酮

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The Changes of Collagen Metabolism in Rat Heart with Type 2 Diabetes and Preventive Effect of Rosiglitazone

WANG Miana,ZHANG Li-huia,ZHAO Zhan-shenga,DENG Yong-guia,ZHOU Honga,HAO Yong-meia,SHU Sheng-oua,CUI Weib

Abstract:

OBJECTIVE To Investigate the changes of collagen accumulation,the MMP-2,MMP-9 and TIMP-1 mRNA expressions in cardiac tissue of the rat with type 2 diabetes at different stages and the role of rosiglitazone.METHODS The experimental type 2 diabetic rats wer

Key words: diabetes mellitus cardiac fibrosis MMPs/TIMPs thiazolidinediones