| 引用本文: | 王晓虹1;孙长凯2;王苏平1;范明3;丁爱石3;吴燕3;马辉2;王禄2.谷胱甘肽抗谷氨酸诱导海马神经元损伤钙超载机制研究[J].中国现代应用药学,2006,(1):13-17. |
| WANG Xiao-hong~(1),SUN Chang-kai~(2),WANG Su-ping~(1),FAN Ming~3,DING Ai-shi~3,WU Yan~3,MA Hui~2,WANG Lu~2.Effect of glutathione on intracellular Ca2+ level of hippocampal neurons caused by glutamate[J].Chin J Mod Appl Pharm(中国现代应用药学),2006,(1):13-17. |
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| 摘要: |
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| 关键词: 兴奋毒性 神经保护 海马神经元 谷胱甘肽 激光扫描共聚焦显微镜 |
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| 基金项目:国家自然科学基金项目(No.30070267);;中国博士后科学基金项目(2001);;辽宁省重点科技攻关项目(No.2001226005)。 |
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| Effect of glutathione on intracellular Ca2+ level of hippocampal neurons caused by glutamate |
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WANG Xiao-hong~(1),SUN Chang-kai~(2),WANG Su-ping~(1),FAN Ming~3,DING Ai-shi~3,WU Yan~3,MA Hui~2,WANG Lu~2
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| Abstract: |
| OBJECTIVE To study the effect of reduced glutathione(GSH) and oxidized glutathione on hippocampal neuron death and intracellular Ca2+ level caused by glutamate and clarify its therapeutical mechanism.METHODS Glutamate cytotoxicity model of primary culture |
| Key words: excitotoxicity neuroprotection hippocampal neurons glutathione laser scanning confocal microscopy |
