| 引用本文: | 杨兆琪;邱国福;粱淑彩;胡先明.肿瘤血管生成抑制剂CA-4的合成[J].中国现代应用药学,2005,(3):210-211. |
| YANG Zhao-qi, QIU Guo-fu, LIANG Shu-cai, HU Xian-ming.Synthesis of tumour vascular inhibitor CA-4[J].Chin J Mod Appl Pharm(中国现代应用药学),2005,(3):210-211. |
|
|
| 摘要: |
| 目的合成针对肿瘤血管的新一代高效低毒抗癌物质CA-4,并改进工艺。方法本文以廉价的异香兰素为起始原料,经过Wittig等六步反应合成CA-4。结果所得产物经IR和1HNMR确证。结论原料廉价,工艺易过渡于工业生产。 |
| 关键词: 抗肿瘤 合成 |
| DOI： |
| 分类号: |
| 基金项目: |
|
| Synthesis of tumour vascular inhibitor CA-4 |
|
YANG Zhao-qi, QIU Guo-fu, LIANG Shu-cai, HU Xian-ming
|
| Abstract: |
| OBJECTIVE To provide a new process for preparing CA-4 used as an agnet for anti-tumour. METHOD The product was synthesized from inexpensive isovanillin by six-step reactions. RESULT The chemical structure of the product was determined by IR and 1HNMR. CON |
| Key words: anti-tumour synthesis |
