引用本文: | 何拥军,罗世能,谢敏浩,刘娅灵,邹霈.雷诺嗪的合成[J].中国现代应用药学,2004,(7):. |
| HE Yong-jun,LUO Shi-neng,XIE Min-hao,LIU Ya-ling,ZOU Pei.Synthesis of Ranolazine[J].Chin J Mod Appl Pharm(中国现代应用药学),2004,(7):. |
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关键词: 雷诺嗪 抗心绞痛 药物化学 工艺改进 合成 |
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Synthesis of Ranolazine |
HE Yong-jun,LUO Shi-neng,XIE Min-hao,LIU Ya-ling,ZOU Pei
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Abstract: |
To synthesize Ranolazine, anew drug for the treatment of antianginal. METHODRanolazine was prepared from 2,6-dimethylaniline by chloacetylation, condensation with piperazine,at last treated with 1-(2-methoxyphenoxy)-2,3-epoxypropane(2) to get Ranolazine.R |
Key words: Ranolazine antianginal medicinal chemistry process improvement synthesis |