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| 摘要: |
| 目的 合成治疗胃溃疡及慢性胃炎的药物索法酮。方法 以对羟基苯甲醛和2 ,4-二羟基苯乙酮为原料,经烃基化、羟醛缩合、水解制得目的物。结果 每步均有改进,总收率达60.8% ,所得产品熔点、IR、1HNMR光谱数据与文献一致。结论 本工艺路线方法简便,原料易得,易工业化生产 |
| 关键词: 胃溃疡 慢性胃炎 索法酮 合成 |
| DOI： |
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| Synthesis of sofalcone with anti-ulcer activity |
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LU Tao, YU Yong-qiang, CAO Fu
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| Abstract: |
| OBJECTIVE To synthesize sofalcone with anti-ulcer and anti-gastritis activity. METHOD With 4-hydroxybenzaldehyde and 2,4-dihydroxyacetophenone as starting materials, sofalcone was synthesized by a four-step procedure, thrice-alkylation and aldol condens |
| Key words: gastric ulcer chronic gastricism sofalcone synthesis |
