| 引用本文: | 姜英子;朴虎日;全哲山;张春波.加巴喷丁的合成工艺改进[J].中国现代应用药学,2004,(1):35-36. |
| JIANG Ying-zi, PIAO Hu-ri, QUAN Zhe-shan, ZHANG Chun-bo.Improved the synthetic method of gabanpentin[J].Chin J Mod Appl Pharm(中国现代应用药学),2004,(1):35-36. |
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| 摘要: |
| 目的 合成加巴喷丁并进行工艺改进。方法 以环己酮为原料,经环合、水解、缩合、氨解和Hoffman降解5步反应合成加巴喷丁。结果 所得产物化学结构经红外光谱、核磁共振谱及质谱等确证,总收率为4 5 %。结论 改进的合成工艺简便、合理且可行。 |
| 关键词: 癫痫 加巴喷丁 合成 |
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| Improved the synthetic method of gabanpentin |
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JIANG Ying-zi, PIAO Hu-ri, QUAN Zhe-shan, ZHANG Chun-bo
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| Abstract: |
| OBJECTIVE To synthesize gabanpentin by improved method. METHOD Gabanpentin was synthesized by 5 steps reaction of cycloaddition , hydrolyzation , condensation , ammonolysis and Hoffman degradation from cyclohexanone. RESULTS Chemical structure of the |
| Key words: falling sickness gabanpentin synthesis |
