| 引用本文: | 旷春桃;胡艾希;王春雷;唐飞.奈非西坦的合成[J].中国现代应用药学,2003,(6):489-490. |
| KUANG Chun-tao, HU Ai-xi,WANG Chun-lei ,TANG Fei.Synthesis of nefiracetam[J].Chin J Mod Appl Pharm(中国现代应用药学),2003,(6):489-490. |
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| 摘要: |
| 目的 合成奈非西坦。方法 以2 ,6-二甲基苯胺为起始原料,经氯乙酰氯N 酰化反应和2-吡咯烷酮的N-烷基化反应合成了奈非西坦。结果 总收率89.9%。对奈非西坦进行了IR ,1HNMR ,13CNMR ,MS确证。结论 该合成工艺可行,具有工业生产价值 |
| 关键词: 奈非西坦 合成 结构表征 |
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| Synthesis of nefiracetam |
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KUANG Chun-tao, HU Ai-xi,WANG Chun-lei ,TANG Fei
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| Abstract: |
| OBJECTIVE To synthesize nefiracetam. METHOD Nefiracetam was synthesized by N acylation of 2,6-dimethylbenzenamine with chloroacetylchloride and N-alkylation of 2-pyrrolidone.RESULTS The overall yield was 89.9%. The structure of nefiracetam was confirm |
| Key words: nefiracetam synthesis characterization |
