大剂量顺铂化疗的药代动力学

翁琳;陈凌亚

引用本文:	翁琳;陈凌亚.大剂量顺铂化疗的药代动力学[J].中国现代应用药学,2002,(4):339-340.
	Weng lin, Chen Lingya.Pharmacokinetic Study of High Dose Cis-platin Chemotherapy[J].Chin J Mod Appl Pharm(中国现代应用药学),2002,(4):339-340.

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大剂量顺铂化疗的药代动力学
翁琳;陈凌亚

作者	单位
翁琳;陈凌亚

摘要:

目的:研究大剂量顺铂化疗的药动学。方法:用HPLC法测定血浆顺铂浓度。结果:血浆顺铂的药代动力学模式为开放二室模型,t1/2α为18.6 0 6min ,t1/2β为4 1.1782h。结论:大剂量顺铂化疗的t1/2β达4 1.1782h ,给药间隔须在三周以上

关键词: 高效液相色谱顺铂药代动力学

DOI：

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基金项目:

Pharmacokinetic Study of High Dose Cis-platin Chemotherapy

Weng lin, Chen Lingya

Abstract:

OBJECTIVE:Studied the pharmacokinetics of High Dose Cis-platin Chemotherapy. METHOD:The Platinum concentration was measured by HPLC.RESULTS:The results showed that the plasma clearance of platinum was biphasic. There was a short initial phase with a half

Key words: HPLC, DDP, pharmacokinetics