| 引用本文: | 张世红;吴立昌1;赵忠林2;洪军1;张春阳1.氯屈膦酸二钠合成工艺改进[J].中国现代应用药学,2001,(1):48-49. |
| Zhang Shihong(Zhang SH),Wu Lichang(Wu LC),Zhao Zhonglin(Zhao ZL),et al.Improved synthesis of clodronate[J].Chin J Mod Appl Pharm(中国现代应用药学),2001,(1):48-49. |
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| 摘要: |
| 目的:对氯屈膦酸二钠的合成工艺进行了研究。方法:以二溴甲烷和亚膦酸三异丙酯为原料,经缩合、氯化、热裂解和成盐反应得到氯屈膦酸二钠。结果:合成产物的化学结构经元素分析、红外光谱、质谱和核磁共振谱确证,总收率为6 0 .3%。结论:此合成路线是完全可行的。 |
| 关键词: 氯屈膦酸二钠 合成 热裂解 |
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| Improved synthesis of clodronate |
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Zhang Shihong(Zhang SH),Wu Lichang(Wu LC),Zhao Zhonglin(Zhao ZL),et al
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| Abstract: |
| OBJECTIVE:To study the synthesis of clodronate.METHODS:Clodronate was synthesized by steps of condensation,chloration,pyrolysis and salifying from dibromomethane and triisopropyl phosphite.RESULTS:The chemical structure of synthetic product was confirmed |
| Key words: clodronate,synthesis,pyrolysis |
