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| 摘要: |
| 目的:改进药物中间体2 -( 2 -噻吩)乙胺的合成方法,使之适合工业化生产。方法:以噻吩为原料,经Vilsmeier反应制得噻吩甲醛,再将Darzen反应、水解、脱羧、与盐酸羟胺缩合等用一锅煮方法制得噻吩-2 -乙醛总收率可达70.09%;;略高于文献。结论:此方法适合工业化生产。 |
| 关键词: 2-(2-噻吩)乙胺 合成 |
| DOI： |
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| Synthesis of 2-(2-Thienyl)ethylamine |
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Liu Tao(Liu T),Yao Aiping(Yao AP),Hu Yongzhou(Hu YZ)
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| Abstract: |
| OBJECTIVE:In order to improve the synthetic method of 2-(2-Thienyl)ethylamine,a key component of a myriad of biologically active materials,and suit for industrial process.METHOD:The target compound was synthesized from thiophene via Vilsmeier's reaction,D |
| Key words: 2-(2-Thienyl)ethylamine,synthesis |
