| 引用本文: | 王礼琛;任进知;韦万武;刘春河.盐酸塞利洛尔合成工艺改进[J].中国现代应用药学,1998,(6):35-36. |
| Wang Lichen ( Wang LC ) , Ren Jinzhi (Ren JZ ) , Wei Wanwu ( Wei WW), et al.Improved synthesis of celiprolol hydrochloride[J].Chin J Mod Appl Pharm(中国现代应用药学),1998,(6):35-36. |
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| 摘要: |
| 目的:合成盐酸塞利洛尔,并进行工艺改进。方法:革除溴化反应,对醚化反应进行了优化。结果:使合成路线缩短一步,醚化收率比文献值提高20%以上。结论:该路线较适合于工业化生产。 |
| 关键词: 盐酸塞1利洛尔 对氨基苯乙醚 N,N-二乙氨基甲酰氯 |
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| Improved synthesis of celiprolol hydrochloride |
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Wang Lichen ( Wang LC ) , Ren Jinzhi (Ren JZ ) , Wei Wanwu ( Wei WW), et al
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| Abstract: |
| OBJECTIVE: Synthesis of celiprolol hydrochloride and the improvement of the process. METHODS:Abolishing of brominating step and optimizing of etherifying reaction. RESULTS: Synthetic route was shorten by one step, the yield of etherification increased by |
| Key words: Celiprolol Hydrocholride ,4 - aminophenylethyl ether, N, N - diethylaminoformyl chloride |
