| 引用本文: | 王志强,范明**,苏运超**,王迪浔**,金咸**.吲哚美辛和乙胺嗪对缺氧大鼠肺血管阻力的影响[J].中国现代应用药学,1994,(3):11-13. |
| Wang Zhiqiang Fan Ming; Su Yunchao; Wang Dixun; Jin Xianrong.Effects of Indomethacin and Diethylcarbamazine on Pulmonary VascularResistance in Rats with Hypoxia[J].Chin J Mod Appl Pharm(中国现代应用药学),1994,(3):11-13. |
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| 摘要: |
| 在慢性和急性缺氧条件下,Hilltop(HT)大鼠肺血管阻力(PVR)升高程度显著比Wistar(WT)大鼠高。吲哚美辛可减少WT大鼠PG2产生,提高PVR;对HT大鼠则减少TXA2产生,降低PVR。乙胺嗪和U-60257B通过抑制5-脂加氧酶使白三烯(LTs)产生减少,在缓解两种大鼠的缺氧性PVR增高中起重要作用。 |
| 关键词: 吲哚美辛 乙胺嗪 肺循环 缺氧 前列腺素 |
| DOI： |
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| 基金项目:国家自然科学基金 |
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| Effects of Indomethacin and Diethylcarbamazine on Pulmonary VascularResistance in Rats with Hypoxia |
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Wang Zhiqiang Fan Ming; Su Yunchao; Wang Dixun; Jin Xianrong
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| Abstract: |
| The pulmonary vascular resistance (PVR) of Hilltop (HT) rats was higher thanthat of Wistar (WT) rats during chronic and acute hypoxia. Indomethacin enhanced PVR inWT rats by decreasing the release of TXA2. Diethylcarbamazine and U-60257B inhibited the5-li |
| Key words: Indomethacin Diethylcarbamazine Pulmonary circulation Anoxia Prostaglandins |
