HPLC法测定人尿中苯妥因及其代谢产物4′—羟基苯妥因

阮邹荣;丁德云

引用本文:	阮邹荣;丁德云.HPLC法测定人尿中苯妥因及其代谢产物4′—羟基苯妥因[J].中国现代应用药学,1993,(1):20-23.
	Ruan ZR Dian DY.HPLC Method for Determination of Phenytoin and its Metabolite 4'-Hydroxyphenytoin in Human Urine[J].Chin J Mod Appl Pharm(中国现代应用药学),1993,(1):20-23.

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HPLC法测定人尿中苯妥因及其代谢产物4′—羟基苯妥因
阮邹荣;丁德云

作者	单位
阮邹荣;丁德云

摘要:

关键词: 苯妥英 4′—羟基苯妥因高效液相色谱遗传代谢多态性

DOI：

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基金项目:浙江省教委科研基金资助

HPLC Method for Determination of Phenytoin and its Metabolite 4'-Hydroxyphenytoin in Human Urine

Ruan ZR Dian DY

Abstract:

A RH-HPLC procedure had been developed for the determination of phenytoin(PHT)and its main metabolite 4'-hydroxyphenytoin(HPPH)in human urine.PHT and HPPH were extr-acted from urine using ether. HPLC was performed on a Bio-Sil(?) ODS column,with a mobilep

Key words: Phenytoin 4′-Hydroxyphenytoin HPLC Genetic polymorphism