| 引用本文: | 杨春要，孙振涛，马风雷，黄运里，李阿丽，韩雪萍.异氟醚和依托咪酯对重症肌无力患者胸腺切除术Bcl-2的影响[J].中国现代应用药学,2011,28(8):774-776. |
| YANG Chunyao, SUN Zhentao, MA Fenglei, HUANG Yunli, LI Ali, HAN Xueping.Effect of Isoflurane and Etomidate on Serum Levels of Bcl-2 in Patients with Myasthenia Gravis Thymectomy[J].Chin J Mod Appl Pharm(中国现代应用药学),2011,28(8):774-776. |
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| 摘要: |
| 目的 探讨异氟醚和依托咪酯对重症肌无力患者胸腺切除术血清Bcl-2的影响。方法 40例重症肌无力胸腺切除术患者，随机分为异氟醚组和依托咪酯组，每组20例。采用ELISA法检测患者术前、术后血清Bcl-2水平的变化。结果 异氟醚组血清Bcl-2术后低于术前(P<0.01)，依托咪酯组血清Bcl-2水平术后高于术前(P<0.01)。两组血清Bcl-2水平术前比较差异无统计学意义(P>0.05)，术后血清Bcl-2水平依托咪酯组高于异氟醚组(P<0.01)。结论 异氟醚用于重症肌无力患者麻醉可降低Bcl-2水平，而依托咪酯则升高Bcl-2水平，异氟醚可能比依托咪酯更适合用于重症肌无力患者胸腺切除术的麻醉。 |
| 关键词: 重症肌无力 胸腺切除术 依托咪酯 异氟醚 |
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| 基金项目:郑州大学研究生科学研究基金项目(2009C3212) |
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| Effect of Isoflurane and Etomidate on Serum Levels of Bcl-2 in Patients with Myasthenia Gravis Thymectomy |
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YANG Chunyao, SUN Zhentao, MA Fenglei, HUANG Yunli, LI Ali, HAN Xueping
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Department of Anesthesiology, the First Affiliated Hospital of Zhengzhou University, Key-disciplines Laboratory Clinical-medicine of Henan Province, Zhengzhou 450052, China
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| Abstract: |
| OBJECTIVE To investigate the effect of isoflurane and etomidate on serum levels of Bcl-2 in patients with myasthenia gravis thymectomy. METHODS Forty patients with myasthenia gravis thymectomy were randomly divided into isoflurane group and etomidate group. The levels of Bcl-2 were measured at preoperative and postoperative with ELISA method. RESULTS The serum Bcl-2 levels postoperative were lower than preoperative in isoflurane group (P<0.01). The serum Bcl-2 levels postoperative were higher than preoperative in etomidate group (P<0.01). There was no significant difference of Bcl-2 serum levels between the two groups before surgery (P>0.05). The Bcl-2 serum levels in etomidate group were higher than isoflurane group postoperative (P<0.01). CONCLUSION Isoflurane can reduce the serum levels of Bcl-2 during thymectomy, while etomidate increases the level of Bcl-2. Isoflurane is more suitable than etomidate for patients with thymectomy. |
| Key words: myasthenia gravis thymectomy etomidate isoflurane |
